Hormonal responses to d- and d,l-fenfluramine in healthy human subjects

被引:38
作者
Coccaro, EF
Kavoussi, RJ
Cooper, TB
Hauger, RL
机构
[1] COLUMBIA UNIV,COLL PHYS & SURG,DEPT PSYCHIAT,ANALYT PSYCHOPHARMACOL LAB,NEW YORK,NY
[2] UNIV CALIF SAN DIEGO,DEPT PSYCHIAT,NEUROSCI RES LAB,SAN DIEGO,CA 92103
关键词
serotonin; fenfluramine; prolactin; ACTH; cortisol;
D O I
10.1016/S0893-133X(96)00133-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Two different doses of d-fenfluramine HCl and d,l-fenfluramine HCl (0.5 ng/kg and 1.0 mg/kg) were administered to 11 healthy male volunteers to compare the neuroendocrine responses to these two forms of fenfluramine in human subjects. Prolactin (PRL) responses to d- and d,l-fenfluramine were significantly greater than those to placebo and were equivalent at both dose levels. Adrenocortiatrophic-releasing hormone (ACTH) and cortisol (CORT) responses to d-fenfluramine at both dose levels were also significantly greater than those to placebo. In contrast, the higher dose of d,l-fenfluramine was associated only with a significant CORT response in comparison to placebo. PRL responses to d-fenfluramine were higher than the PRL response to d,l-fenfluramine at either dose level. The PRL response to d-fenfluramine at 0.5 mg/kg was very highly correlated with the PRL responses to d,l-fenfluramine at 1.0 mg/kg (r = 0.97, n = 10). Homovanillic acid (HVA) were not altered by either d, or d,l-fenfluramine at either dose in a subsample of subjects (n = 4). ACTH/CORT responses to d- and d,l-fenfluramine were modestly intercorrelated. These data suggest that the PRL response evoked by d-fenfluramine is quantitatively very similar to that evoked by d,l-fenfluramine. (C) 1996 American College of Neuropsychopharmacology
引用
收藏
页码:595 / 607
页数:13
相关论文
共 24 条
[1]   NEUROENDOCRINE REGULATION OF PROLACTIN-RELEASE [J].
BENJONATHAN, N ;
ARBOGAST, LA ;
HYDE, JF .
PROGRESS IN NEUROBIOLOGY, 1989, 33 (5-6) :399-447
[2]  
COCCARO EF, 1994, CLIN CHEM, V40, P319
[3]   5-HT2a/2c, receptor blockade by amesergide fully attenuates prolactin response to d-fenfluramine challenge in physically healthy human subjects [J].
Coccaro, EF ;
Kavoussi, RJ ;
Oakes, M ;
Cooper, TB ;
Hauger, R .
PSYCHOPHARMACOLOGY, 1996, 126 (01) :24-30
[4]   REDUCED PROLACTIN RESPONSE TO FENFLURAMINE CHALLENGE IN PERSONALITY-DISORDER PATIENTS IS NOT DUE TO DEFICIENCY OF PITUITARY LACTOTROPHS [J].
COCCARO, EF ;
KLAR, H ;
SIEVER, LJ .
BIOLOGICAL PSYCHIATRY, 1994, 36 (05) :344-346
[5]   EFFECTS OF D-FENFLURAMINE AND 1-FENFLURAMINE ON STRIATAL HOMOVANILLIC-ACID CONCENTRATIONS IN RATS AFTER PHARMACOLOGICAL MANIPULATION OF BRAIN-SEROTONIN [J].
CRUNELLI, V ;
BERNASCONI, S ;
SAMANIN, R .
PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1980, 12 (03) :215-223
[6]  
GARATTINI S, 1988, CLIN NEUROPHARMACOL, V11, pS8
[7]   FROM FENFLURAMINE RACEMATE TO D-FENFLURAMINE - SPECIFICITY AND POTENCY OF THE EFFECTS ON THE SEROTONINERGIC SYSTEM AND FOOD-INTAKE [J].
GARATTINI, S ;
MENNINI, T ;
SAMANIN, R .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 499 :156-166
[8]   PROLACTIN AND TSH RESPONSES TO BOTH DOMPERIDONE AND TRH IN NORMAL AND HYPERPROLACTINAEMIC WOMEN AFTER DOPAMINE SYNTHESIS BLOCKADE [J].
GHIGO, E ;
GOFFI, S ;
MOLINATTI, GM ;
CAMANNI, F ;
MASSARA, F .
CLINICAL ENDOCRINOLOGY, 1985, 23 (02) :155-160
[9]   RITANSERIN ATTENUATES ANORECTIC, ENDOCRINE AND THERMAL RESPONSES TO D-FENFLURAMINE IN HUMAN VOLUNTEERS [J].
GOODALL, EM ;
COWEN, PJ ;
FRANKLIN, M ;
SILVERSTONE, T .
PSYCHOPHARMACOLOGY, 1993, 112 (04) :461-466
[10]   PLASMA PROLACTIN, ADRENOCORTICOTROPIC HORMONE AND CORTISOL AFTER ADMINISTRATION OF D-FENFLURAMINE OR PLACEBO TO HEALTHY-SUBJECTS [J].
GORARD, DA ;
TAYLOR, TM ;
MEDBAK, SH ;
PERRY, LA ;
LIBBY, GW ;
FARTHING, MJG .
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1993, 8 (02) :123-128