A computer program based on parallel line assay for analysis of skin tests

被引:20
作者
Martin, S [1 ]
Cuesta, P [1 ]
Rico, P [1 ]
Cortes, C [1 ]
机构
[1] UNIV COMPLUTENSE MADRID,CTR PROCESO DATOS,MADRID,SPAIN
关键词
allergens; immunotherapy; parallel line assay; skin tests;
D O I
10.1111/j.1398-9995.1997.tb02552.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
A computer program for the analysis of differences or changes in skin sensitivity has been developed. It is based on parallel line assay, and its main features are its ability to conduct a validation process which ensures that the data from skin tests conform to the conditions imposed by the analysis which is carried out (regression, parallelism, etc.), the estimation of the difference or change in skin sensitivity, and the determination of the 95% and 99% confidence intervals of this estimation. This program is capable of managing data from independent groups, as well as paired data, and it may be applied to the comparison of allergen extracts, with the aim of determining their biologic activity, as well as to the analysis of changes in skin sensitivity appearing as a consequence of treatment such as immunotherapy.
引用
收藏
页码:97 / 100
页数:4
相关论文
共 19 条
[1]  
BASOMBA A, 1993, ALLERGY S14, V43, P71
[2]   DOUBLE-BLIND, PLACEBO-CONTROLLED IMMUNOTHERAPY WITH MIXED GRASS-POLLEN ALLERGOIDS .3. EFFICACY AND SAFETY OF UNFRACTIONATED AND HIGH-MOLECULAR-WEIGHT PREPARATIONS IN RHINOCONJUNCTIVITIS AND ASTHMA [J].
BOUSQUET, J ;
MAASCH, HJ ;
HEJJAOUI, A ;
SKASSABROCIEK, W ;
WAHL, R ;
DHIVERT, H ;
MICHEL, FB .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1989, 84 (04) :546-556
[3]  
BUCUR J, 1989, ANN ALLERGY, V62, P355
[4]  
CUESTA EA, 1992, REV ESP ALERGOL INMU, V7, P55
[5]  
CUESTA EA, 1994, J ALLERGY CLIN IMMUN, V93, P556
[6]   DOSE-RESPONSE RELATIONSHIP OF ALLERGEN, HISTAMINE, AND HISTAMINE RELEASERS IN SKIN PRICK TEST AND PRECISION OF THE SKIN PRICK TEST METHOD [J].
DREBORG, S ;
HOLGERSSON, M ;
NILSSON, G ;
ZETTERSTROM, O .
ALLERGY, 1987, 42 (02) :117-125
[7]  
Dreborg S., 1993, ALLERGY, V14, P63, DOI [10.1111/ j.1398-9995.1993.tb04759.x, DOI 10.1111/J.1398-9995.1993.TB04759.X]
[8]  
DREBORG S, 1987, SKIN PRICK TEST METH, P133
[9]  
FINNEY DJ, 1978, STATISTICAL METHOD B
[10]   DOSE-RESPONSE CURVE OF ALLERGEN AND HISTAMINE IN SKIN PRICK TESTS [J].
HARRIS, RI ;
STERN, MA ;
WATSON, HK .
ALLERGY, 1988, 43 (08) :565-572