Microsatellite instability in gastric cancer prone families

被引：15

作者：

Sasaki, A

Nagashima, M

Shiseki, M

Katai, H

Maruyama, K

Iwanaga, R

Akiyama, Y

Yuasa, Y

Yokota, J

机构：

[1] NATL CANC RES INST,DIV BIOL,CHUO KU,TOKYO 104,JAPAN

[2] NATL CANC CTR,DEPT SURG,CHUO KU,TOKYO 104,JAPAN

[3] TOKYO MED & DENT UNIV,SCH MED,DEPT HYG & ONCOL,BUNKYO KU,TOKYO 113,JAPAN

来源：

CANCER LETTERS | 1996年 / 99卷 / 02期

关键词：

microsatellite instability; gastric cancer; cancer prone family; hMSH2; hMLH1; p53;

D O I：

10.1016/0304-3835(95)04048-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined for germ-line p53 mutations and microsatellite instability in three gastric cancer patients who had family histories of gastric cancer aggregation. Although no germ-line p53 mutation was detected in these three cases, the replication error (RER) phenotype was observed in two of them. One base deletion in the sequence of ten repeating adenines of the type II transforming growth factor-beta receptor gene was detected in one of these two cases. Furthermore, there were young patients of 50 years and downward in their families. Therefore, it is possible that inherited disorders in mismatch repair systems contribute to high susceptibility to gastric cancers in these families.

引用

页码：169 / 175

页数：7

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