Base-specific interaction of polymers containing adenine: effect of chiral spacer on the interaction with polynucleotide

被引：1

作者：

Inaki, Y ^{[1
]}

Kamo, S ^{[1
]}

Miyata, M ^{[1
]}

机构：

[1] Osaka Univ, Dept Mat & Life Sci, Suita, Osaka 565, Japan

来源：

REACTIVE & FUNCTIONAL POLYMERS | 1998年 / 37卷 / 1-3期

关键词：

adenine; L-Serine; D-Serine; polyethyleneimine; polynucleotide; poly U; interaction;

D O I：

10.1016/S1381-5148(97)00118-1

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Polyethyleneimine derivatives of adenine with L- and D-serine as spacers were prepared. The polymer having D-serine spacer 2 gave a stable polymer complex with poly(uridylic acid) (poly U), but the polymer having L-serine spacer 1 gave an unstable polymer complex. The reason was concluded to be caused by the steric repulsion of L-serine units along the polymer chain when the polymer formed polymer complex with poly U. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：189 / 198

页数：10

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