Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries

被引：189

作者：

Fujii, N ^{[1
]}

Oishi, S

Hiramatsu, K

Araki, T

Ueda, S

Tamamura, H

Otaka, A

Kusano, S

Terakubo, S

Nakashima, H

Broach, JA

Trent, JO

Wang, ZX

Peiper, SC

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

[2] St Marianna Univ, Sch Med, Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan

[3] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

[4] Univ Louisville, James Graham Brown Canc Ctr, Louisville, KY 40202 USA

[5] Med Coll Georgia, Dept Pathol, Augusta, GA 30912 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 28期

关键词：

antagonists; antiviral agents; drug design; high-throughput screening; peptides;

D O I：

10.1002/anie.200351024

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：3251 / 3253

页数：3

共 18 条

[1] Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells [J].

Burger, JA ;

Burger, M ;

Kipps, TJ .

BLOOD, 1999, 94 (11) :3658-3667

[2] HIV-1 Entry Cofactor: Functional cDNA Cloing of a Seven-Transmembrane, G protein-Coupled Receptor [J].

Feng, Yu ;

Broder, Christopher C. ;

Kennedy, Paul E. ;

Berger, Edward A. .

JOURNAL OF IMMUNOLOGY, 2011, 186 (11) :872-877

[3]

Fujii N, 2001, Curr Opin Investig Drugs, V2, P1198

[4] STRUCTURE-ACTIVITY-RELATIONSHIPS OF CYCLIC PENTAPEPTIDE ENDOTHELIN-A RECEPTOR ANTAGONISTS [J].

FUKAMI, T ;

NAGASE, T ;

FUJITA, K ;

HAYAMA, T ;

NIIYAMA, K ;

MASE, T ;

NAKAJIMA, S ;

FUKURODA, T ;

SAEKI, T ;

NISHIKIBE, M ;

IHARA, M ;

YANO, M ;

ISHIKAWA, K .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (21) :4309-4324

[5] Structural and functional aspects of RGD-containing cyclic pentapeptides as highly potent and selective integrin alpha(v)beta(3) antagonists [J].

Haubner, R ;

Gratias, R ;

Diefenbach, B ;

Goodman, SL ;

Jonczyk, A ;

Kessler, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (32) :7461-7472

[6]

Haubner R., 1997, ANGEW CHEM, V109, P1440

[7]

Haubner R., 1997, ANGEW CHEM INT EDIT, V36, P1374

[8] Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads [J].

Hruby, VJ ;

Balse, PM .

CURRENT MEDICINAL CHEMISTRY, 2000, 7 (09) :945-970

[9] Novel peptidomimetics of the antifungal cyclic peptide rhodopeptin: Synthesis of mimetics and their antifungal activity [J].

Kawato, HC ;

Nakayama, K ;

Inagaki, H ;

Ohta, T .

ORGANIC LETTERS, 2001, 3 (22) :3451-3454

[10]

KESSLER H, 1985, PEPTIDES 1985, P83

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