MAPs, MARKs and microtubule dynamics

被引：286

作者：

Drewes, G ^{[1
]}

Ebneth, A ^{[1
]}

Mandelkow, EM ^{[1
]}

机构：

[1] Max Planck Unit Struct Mol Biol, D-22603 Hamburg, Germany

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 08期

关键词：

D O I：

10.1016/S0968-0004(98)01245-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microtubules (MTs) serve as tracks for cellular transport, and regulate cell shape and polarity. Rapid transitions between stable and dynamic forms of MTs are central to these processes, This dynamic instability is regulated by a number of cellular factors, including the structural MT-associated proteins (MAPs), which in turn are regulated by phosphorylation. MT-affinity-regulating kinases (MARKs) are novel mammalian serine/threonine kinases that phosphorylate the tubulin-binding domain of MAPs and thereby cause their detachment from MTs and increased MT dynamics. Molecular cloning of MARKs revealed a family of four closely related protein kinases that share homology with genes from the nematode Caenorhabditis elegans and fission yeast that are involved in the generation of cell shape and polarity, Hence, MARKs might play a role in the regulation of MT stability during morphogenesis.

引用

页码：307 / 311

页数：5

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