Does therapeutic intervention achieve slowing of progression or bona fide regression of atherosclerotic lesions?

被引:33
作者
Stein, Y [1 ]
Stein, O [1 ]
机构
[1] Hadassah Univ Hosp, Div Med, Lipid Res Lab, IL-91120 Jerusalem, Israel
关键词
atherosclerosis; prevention of CAD; fatty streaks; complex lesion; gene therapy;
D O I
10.1161/01.ATV.21.2.183
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This review focuses on the regression of atherosclerosis in humans and experimental animals. It highlights the difficulties to determine unequivocally whether with a given therapeutic intervention, such as diet, drugs, or apheresis, the progression of lesions was curtailed or bona fide regression of atherosclerotic lesions was achieved. It seems appropriate to mention that 2 very different ways to measure regression were used in experimental animals and in humans. Regression in animals was determined mainly in the aorta or coronary arteries isolated at post mortem, and the criteria used were degree of sudanophilia and/or aortic wall thickness and cellular composition or cholesterol content. In humans, the evaluation of regression relied mainly on quantitative coronary angiography. The literature of the past decade is reviewed selectively but not exhaustively, and in some instances, a brief historical overview is given.
引用
收藏
页码:183 / 188
页数:6
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