Synthesis and biological evaluation of gemcitabine-lipid conjugate (NE06002)

被引：43

作者：

Ali, SM ^{[1
]}

Khan, AR ^{[1
]}

Ahmad, MU ^{[1
]}

Chen, P ^{[1
]}

Sheikh, S ^{[1
]}

Ahmad, I ^{[1
]}

机构：

[1] NeoPharm Inc, Res & Dev Facil, Waukegan, IL 60085 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 10期

关键词：

gemcitabine; lipid-nucleoside conjugate; cardiolipin; prodrug;

D O I：

10.1016/j.bmcl.2005.03.046

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel gemcitabine-lipid conjugate 5 was synthesized and tested for its in vivo efficacy and toxicity. Compound 5 was tested in BxPC-3 human pancreatic tumor model in SCID mice and exhibited promising activity and lower toxicity when compared with Gerrizar (R). (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：2571 / 2574

页数：4

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