Effects of exogenous interleukin-6 during Pseudomonas aeruginosa corneal infection

被引：37

作者：

Cole, N

Krockenberger, M

Bao, SS

Beagley, KW

Husband, AJ

Willcox, M ^{[1
]}

机构：

[1] Univ New S Wales, Sch Optometry, CRCERT, Sydney, NSW 2052, Australia

[2] Univ New S Wales, Cooperat Res Ctr Eye Res & Technol, Cornea & Contact Lens Res Unit, Sydney, NSW 2052, Australia

[3] Univ Sydney, Dept Vet Anat & Pathol, Sydney, NSW 2006, Australia

[4] Univ Newcastle, Fac Med, Discipline Pathol, Newcastle, NSW 2308, Australia

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 06期

关键词：

D O I：

10.1128/IAI.69.6.4116-4119.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Lack of interleukin-6 (IL-6) during Pseudomonas aeruginosa corneal infection leads to more severe disease with changes in neutrophil recruitment. Exogenous IL-6 leads to increased efficiency of neutrophil recruitment and reduced bacterial loads in corneal infection in both IL-6 gene knockout and wild-type mice. This may be mediated by IL-6 increasing the production of corneal macrophage inflammatory protein 2 and intercellular cell adhesion molecule 1. We conclude that effective recruitment of neutrophils into the cornea is dependent on the production of IL-6 and that early augmentation of IL-6 may be protective in corneal infection.

引用

收藏

页码：4116 / 4119

页数：4

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