Lysyl oxidase mediates hypoxic control of metastasis

被引：162

作者：

Erler, Janine T. ^{[1
]}

Giaccia, Amato J. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Radiat Oncol, Stanford, CA 94305 USA

来源：

CANCER RESEARCH | 2006年 / 66卷 / 21期

关键词：

D O I：

10.1158/0008-5472.CAN-06-3197

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Hypoxic cancer cells pose a great challenge to the oncologist because they are especially aggressive, metastatic, and resistant to therapy. Recently, we showed that elevation of the extracellular matrix protein lysyl oxidase (LOX) correlates with metastatic disease and is essential for hypoxia-induced metastasis. In an orthotopic rodent model of breast cancer, a small-molecule or antibody inhibitor of LOX abolished metastasis, offering preclinical validation of this enzyme as a therapeutic target.

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收藏

页码：10238 / 10241

页数：4

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