Review of cell and particle trapping in microfluidic systems

被引：433

作者：

Nilsson, J. ^{[1
]}

Evander, M. ^{[1
]}

Hammarstrom, B. ^{[1
]}

Laurell, T. ^{[1
]}

机构：

[1] Lund Univ, Dept Measurement Technol & Ind Elect Engn, Div Nanobiotechnol, Lund, Sweden

来源：

ANALYTICA CHIMICA ACTA | 2009年 / 649卷 / 02期

关键词：

Cell handling; Cell trapping; Microfluidics; Lab-on-a-chip; STANDING-WAVE TRAP; PATCH-CLAMP ARRAY; OPTICAL TWEEZERS; ON-CHIP; MAGNETIC TWEEZERS; BIOMEDICAL ANALYSIS; ADHESION DYNAMICS; ULTRASONIC FORCES; RADIATION FORCE; CULTURE ARRAY;

D O I：

10.1016/j.aca.2009.07.017

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The ability to obtain ideal conditions for well-defined chemical microenvironments and controlled temporal chemical and/or thermal variations holds promise of high-resolution cell response studies, cell-cell interactions or e.g. proliferation conditions for stem cells. It is a major motivation for the rapid increase of lab-on-a-chip based cell biology research. In view of this, new chip-integrated technologies are at an increasing rate being presented to the research community as potential tools to offer spatial control and manipulation of cells in microfluidic systems. This is becoming a key area of interest in the emerging lab-on-a-chip based cell biology research field. This review focuses on the different technical approaches presented to enable trapping of particles and cells in microfluidic system. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：141 / 157

页数：17

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