BDNF is required for the normal development of taste neurons in vivo

被引：79

作者：

Zhang, CX ^{[1
]}

Brandemihl, A ^{[1
]}

Lau, D ^{[1
]}

Lawton, A ^{[1
]}

Oakley, B ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT BIOL,ANN ARBOR,MI 48109

来源：

NEUROREPORT | 1997年 / 8卷 / 04期

关键词：

brain-derived neurotrophic factor; foliate papillae; gustatory; immunocytochemistry; keratin; 8; knockout mouse; null mutant; taste bud; tyrosine kinase receptor B; vallate papilla;

D O I：

10.1097/00001756-199703030-00039

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE vallate gustatory epithelium of neonatal trkB null mutant mice (-/-) lacked innervation. This prompted the evaluation of null mutant mice corresponding to the three neurotrophin ligands for tyrosine kinase receptor B (TrkB): brain-derived neurotrophic factor (BDNF), neurotrophin (NT)3, NT4. The vallate gustatory epithelium of nt3-/- mice and of nt4-/- mice appeared normal. Only bdnf-/- mice had a vallate papilla that was stunted, sparsely innervated, and lacked up to 98% of its taste buds. All three defects persisted. For example, the vallate papilla of 12-day-old bdnf-/- mice remained markedly less well innervated than the vallate of 7-day-old or newborn bdnf+/+ mice. The foliate taste papillae of neonatal bdnf-/- mice had similar defects. We conclude that the normal development of taste neurons requires BDNF.

引用

页码：1013 / 1017

页数：5

共 25 条

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