Sex-based differences in physiology: what should we teach in the medical curriculum?

被引:46
作者
Blair, Martha L. [1 ]
机构
[1] Univ Rochester, Sch Med & Dent, Dept Physiol & Pharmacol, Rochester, NY 14642 USA
关键词
sex characteristics; gonadal steroid hormones; cardiovascular physiology; AUTOIMMUNITY; STEROIDS; HORMONES; SYSTEM;
D O I
10.1152/advan.00118.2006
中图分类号
G40 [教育学];
学科分类号
040101 [教育学原理];
摘要
An abundance of recent research indicates that there are multiple differences between males and females both in normal physiology and in the pathophysiology of disease. The Refresher Course on Gender Differences in Physiology, sponsored by the American Physiological Society Education Committee at the 2006 Experimental Biology Meeting in San Franciso, CA, was designed to provide teachers of medical physiology with the background necessary to include the most important aspects of sex-based differences in their curricula. The presentations addressed sex-based differences in the physiology and pathophysiology of the cardiovascular, musculoskeletal, and immune systems as well as the cellular mechanisms of sex steroid hormone actions on nonreproductive tissues. The slides and audio files for these presentations are available at http://www.the-aps.org/education/refresher/index.htm. This overview highlights the key concepts relevant to the topic of sex-based differences in physiology: why these differences are important, their potential causes, and examples of prominent differences between males and females in normal physiological function for selected organ systems.
引用
收藏
页码:23 / 25
页数:3
相关论文
共 14 条
[1]
Changes in renal hemodynamics and structure in the aging kidney; sexual dimorphism and the nitric oxide system [J].
Baylis, C .
EXPERIMENTAL GERONTOLOGY, 2005, 40 (04) :271-278
[2]
AGE AND SEX ASSOCIATIONS OF 40 AUTOIMMUNE-DISEASES [J].
BEESON, PB .
AMERICAN JOURNAL OF MEDICINE, 1994, 96 (05) :457-462
[3]
A role for transcription factor NF-κB in autoimmunity:: possible interactions of genes, sex, and the immune response [J].
Dale, Elizabeth ;
Davis, Miriam ;
Faustman, Denise L. .
ADVANCES IN PHYSIOLOGY EDUCATION, 2006, 30 (04) :152-158
[4]
Fagan TF, 2004, ADV MOL CEL, V34, P295, DOI 10.1016/S1569-2558(03)34020-2
[5]
Does gender affect pulmonary function and exercise capacity? [J].
Harms, CA .
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2006, 151 (2-3) :124-131
[6]
Legato M. J., 2004, PRINCIPLES GENDER SP, P185
[7]
When is a sex difference not a sex difference? [J].
McCarthy, MM ;
Konkle, ATM .
FRONTIERS IN NEUROENDOCRINOLOGY, 2005, 26 (02) :85-102
[8]
Neuroactive steroids: Old players in a new game [J].
Melcangi, RC ;
Panzica, GC .
NEUROSCIENCE, 2006, 138 (03) :733-739
[9]
Molecular and cellular basis of cardiovascular gender differences [J].
Mendelsohn, ME ;
Karas, RH .
SCIENCE, 2005, 308 (5728) :1583-1587
[10]
Pham TV, 2004, ADV MOL CEL, V34, P115, DOI 10.1016/S1569-2558(03)34009-3