Allylmercaptocaptopril: A new antihypertensive drug

被引：15

作者：

Miron, T

Rabinkov, A

Peleg, E

Rosenthal, T ^{[1
]}

Mirelman, D

Wilchek, M

机构：

[1] Chaim Sheba Med Ctr, Chorley Inst Hypertens Res, IL-2621 Tel Hashomer, Israel

[2] Weizmann Inst Sci, IL-76100 Rehovot, Israel

[3] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel

来源：

AMERICAN JOURNAL OF HYPERTENSION | 2004年 / 17卷 / 01期

关键词：

allylmercaptocaptopril; allicin; captopril; hypertension; hyperinsulinemia; hypertriglyceridemia;

D O I：

10.1016/S0895-7061(03)01035-5

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Allylmercaptocaptopril (CPSSA) was synthesized by reacting captopril with pure allicin. Fructose-induced hypertensive groups of rats were fed a fructose-rich diet for 3 weeks, and then received the diet plus either CPSSA (40 to 56 mg or 138 to 194 mumol/L/kg/d) or captopril (80 mg or 369 mumol/L/kg/d) for 2 more weeks. CPSSA (both doses) significantly lowered blood pressure (BP) from 153.4 to 120.8 mm Hg (P < .005). Captopril gave similar results, lowering, BP from 150.7 to 123 mm Hg (P < .005). CPSSA also decreased the high levels of triglycerides to normal. The new stable compound allylmercaptocaptopril combines the beneficial properties of captopril and allicin and is a potential candidate for antihypertensive drug therapy. (C) 2004 American Journal of Hypertension, Ltd.

引用

页码：71 / 73

页数：3

共 15 条

[1] Allicin-induced decrease in formation of fatty streaks (atherosclerosis) in mice fed a cholesterol-rich diet [J].