Therapeutic perspectives of adipocytokines

被引:50
作者
Kralisch, S [1 ]
Klein, J [1 ]
Bluher, M [1 ]
Paschke, R [1 ]
Stumvoll, M [1 ]
Fasshauer, M [1 ]
机构
[1] Univ Leipzig, Dept Internal Med 3, D-04103 Leipzig, Germany
关键词
adiponectin; diabetes mellitus; insulin resistance; IL-6; leptin; obesity; omentin; plasminogen activator inhibitor-1; resistin; TNF-alpha; visfatin;
D O I
10.1517/14656566.6.6.863
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Various adipocyte-secreted factors have been described which profoundly affect insulin sensitivity and might potentially link obesity, insulin resistance and cardiovascular disease. Among those, adiponectin, visfatin and omentin appear as insulin-sensitising adipocytokines, whereas TNF-alpha, IL-6 and resistin induce insulin resistance. Moreover, leptin is a fat-derived key regulator of appetite and energy expenditure. Due to their profound effect on whole-body glucose and energy metabolism, adipocytokines have attracted interest as potential new therapeutics for diabetes mellitus and obesity. The current knowledge on function, regulation and therapeutic potential of various adipocytokines, as well as their clinical implications, are discussed in this review.
引用
收藏
页码:863 / 872
页数:10
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