Cytapheresis in inflammatory bowel diseases: Current evidence and perspectives

被引:8
作者
Danese, Silvio [1 ]
Angelucci, Erika [2 ]
Stefanelli, Tommaso [1 ]
Omodei, Paolo [1 ]
Luigiano, Carmelo [1 ]
Finazzi, Silvia [1 ]
Pagano, Nico [1 ]
Repici, Alessandro [1 ]
Vecchi, Maurizio [3 ]
Malesci, Alberto [1 ]
机构
[1] Univ Milan, Div Gastroenterol, Ist Clin Humanitas, IRCCS Gastroenterol, IT-20089 Milan, Italy
[2] Univ Sapienza, Div Gastroenterol, Policlin Umberto I, Rome, Italy
[3] Univ Milan, IRCCS Policlin San Donato Milanese, Div Gastroenterol, Milan, Italy
关键词
D O I
10.1159/000122473
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Ulcerative colitis and Crohn's disease are inflammatory bowel diseases with a chronic relapsing course. Management of both conditions is far from being fully satisfactory. For this reason in the last decade a large number of biological therapies, targeting cytokines involved in intestinal inflammation, has been developed with various results in terms of efficacy, safety and costs. Activated granulocytes and monocytes represent the major sources of pro-inflammatory cytokines in the intestinal mucosa, playing a pivotal role in inducing and maintaining intestinal inflammation. Leukocytapheresis using an adsorptive carrier-based system (Adacolumn (R)) or a removal filter column (Cellsorba (R)) has been proposed as a feasible, safe and effective therapy for ulcerative colitis and Crohn's disease. The objective of this paper is to provide an overview on the current knowledge about mechanisms of action, available clinical data and the possible future perspectives for the use of Adacolumn and Cellsorba in the management of inflammatory bowel diseases. Copyright (C) 2008 S. Karger AG, Basel.
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收藏
页码:96 / 107
页数:12
相关论文
共 69 条
[1]
Leukocytapheresis therapy modulates circulating T cell subsets in patients with ulcerative colitis [J].
Andoh, A ;
Tsujikawa, T ;
Inatomi, O ;
Deguchi, Y ;
Sasaki, M ;
Obata, H ;
Mitsuyama, K ;
Fujiyama, Y .
THERAPEUTIC APHERESIS AND DIALYSIS, 2005, 9 (03) :270-276
[2]
Suppression of inflammatory cytokine secretion by granulocyte/monocyte adsorptive apheresis in active ulcerative colitis [J].
Andoh, A ;
Tsujikawa, T ;
Inatomi, O ;
Deguchi, Y ;
Hata, K ;
Kitoh, K ;
Sasaki, M ;
Mitsuyama, K ;
Fujiyama, Y .
THERAPEUTIC APHERESIS AND DIALYSIS, 2005, 9 (02) :123-127
[3]
Suppression of interleukin-1β- and tumor necrosis factor-α-induced inflammatory responses by leukocytapheresis therapy in patients with ulcerative colitis [J].
Andoh, A ;
Ogawa, A ;
Kitamura, K ;
Inatomi, O ;
Fujino, S ;
Tsujikawa, T ;
Sasaki, M ;
Mitsuyama, K ;
Fujiyama, Y .
JOURNAL OF GASTROENTEROLOGY, 2004, 39 (12) :1150-1157
[4]
Leukocytapheresis for ulcerative colitis: A comparative study of anticoagulant (Nafamostat mesilate vs. Dalteparin sodium) for reducing clinical complications [J].
Ashizuka, S ;
Nishiura, R ;
Ishikawa, N ;
Yamaga, J ;
Inatsu, H ;
Fujimoto, S ;
Eto, T .
THERAPEUTIC APHERESIS AND DIALYSIS, 2006, 10 (01) :54-58
[5]
THE CURRENT STATUS OF LYMPHOCYTE-T APHERESIS (TLA) TREATMENT OF CROHNS-DISEASE [J].
BICKS, RO ;
GROSHART, KD .
JOURNAL OF CLINICAL GASTROENTEROLOGY, 1989, 11 (02) :136-138
[6]
Mucosal features and granulocyte-monocyte-apheresis in steroid-dependent/refractory ulcerative colitis [J].
D'Ovidio, V. ;
Aratari, A. ;
Viscido, A. ;
Marcheggiano, A. ;
Papi, C. ;
Capurso, L. ;
Caprilli, R. .
DIGESTIVE AND LIVER DISEASE, 2006, 38 (06) :389-394
[7]
DARRIGO C, 1995, CLIN EXP IMMUNOL, V100, P173
[8]
Granulocyteaphaeresis in steroid-dependent inflammatory bowel disease:: a prospective, open, pilot study [J].
Domènech, E ;
Hinojosa, J ;
Esteve-Comas, M ;
Gomollón, F ;
Herrera, JM ;
Bastida, G ;
Obrador, A ;
Ruiz, R ;
Saro, C ;
Gassull, MA .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2004, 20 (11-12) :1347-1352
[9]
REGULATION OF CELL-ADHESION MOLECULE EXPRESSION AND FUNCTION-ASSOCIATED WITH NEUTROPHIL APOPTOSIS [J].
DRANSFIELD, I ;
STOCKS, SC ;
HASLETT, C .
BLOOD, 1995, 85 (11) :3264-3273
[10]
Leukocytapheresis (LCAP) in the management of chronic active ulcerative colitis-results of a randomized pilot trial [J].
Emmrich, Joerg ;
Petermann, Sebastian ;
Nowak, Dietrich ;
Beutner, Ingolf ;
Brock, Peter ;
Klingel, Reinhard ;
Mausfeld-Lafdhiya, Patrick ;
Liebe, Stefan ;
Ramlow, Wolfgang .
DIGESTIVE DISEASES AND SCIENCES, 2007, 52 (09) :2044-2053