A Role for Peroxisome Proliferator-Activated Receptors in the Immunopathology of Schistosomiasis?

被引：14

作者：

Anthony, Barrie J. ^{[1
]}

Allen, Jeremy T. ^{[2
]}

Li, Yuesheng S. ^{[1
]}

McManus, Donald P. ^{[1
]}

机构：

[1] Royal Brisbane Hosp, Post Off, Queensland Inst Med Res, Brisbane, Qld 4029, Australia

[2] Univ Salford, Dept Biol, Ctr Parasitol & Dis, Biomed Sci Res Inst, Manchester M5 4WT, Lancs, England

来源：

PPAR RESEARCH | 2012年 / 2012卷

基金：

英国医学研究理事会;

关键词：

HEPATIC STELLATE CELLS; MACROPHAGES; MANSONI; FIBROSIS; EXPRESSION; TISSUE; INFECTION; RESPONSES; PREVENTS; AGONIST;

D O I：

10.1155/2012/128068

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Peroxisome proliferator-activated receptors (PPARs) have been demonstrated to have a role in immune regulation. In general, they are anti-inflammatory and promote Th2 type responses, and they are associated with the alternative activation of macrophages. Interestingly, helminth infections, such as the schistosome blood flukes that cause schistosomiasis, are characterised by a Th2 response and the accumulation of alternative activated macrophages. This would suggest that at some level, PPARs could have a role in the modulation of the immune response in schistosomiasis. This paper discusses possible areas where PPARs could have a role in this disease.

引用

页数：6

共 55 条

[1]

Hepatic stellate cells and parasite-induced liver fibrosis [J].

Anthony, Barrie ;

Allen, Jeremy T. ;

Li, Yuesheng S. ;

McManus, Donald P. .

PARASITES & VECTORS, 2010, 3

[2]

Schistosoma mansoni: Egg-induced downregulation of hepatic stellate cell activation and fibrogenesis [J].

Anthony, Barrie ;

Mathieson, William ;

de Castro-Borges, William ;

Allen, Jeremy .

EXPERIMENTAL PARASITOLOGY, 2010, 124 (04) :409-420

[3]

Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites [J].

Anthony, Robert M. ;

Urban, Joseph F., Jr. ;

Alem, Farhang ;

Hamed, Hossein A. ;

Rozo, Cristina T. ;

Boucher, Jean-Luc ;

Van Rooijen, Nico ;

Gause, William C. .

NATURE MEDICINE, 2006, 12 (08) :955-960

[4]

Telmisartan prevents the progression of renal injury in daunorubicin rats with the alteration of angiotensin II and endothelin-1 receptor expression associated with its PPAR-γ agonist actions [J].

Arozal, Wawaimuli ;

Watanabe, Kenichi ;

Veeraveedu, Punniyakoti T. ;

Ma, Meilei ;

Thandavarayan, Rajarajan A. ;

Sukumaran, Vijayakumar ;

Suzuki, Kenji ;

Kodama, Makoto ;

Aizawa, Yoshifusa .

TOXICOLOGY, 2011, 279 (1-3) :91-99

[5]

A contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis [J].

Bartley, Paul B. ;

Ramm, Grant A. ;

Jones, Malcolm K. ;

Ruddell, Richard G. ;

Li, Yuesheng ;

McManus, Donald P. .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2006, 36 (09) :993-1001

[6]

Immunopathogenesis of human schistosomiasis [J].

Burke, M. L. ;

Jones, M. K. ;

Gobert, G. N. ;

Li, Y. S. ;

Ellis, M. K. ;

Mcmanus, D. P. .

PARASITE IMMUNOLOGY, 2009, 31 (04) :163-176

[7]

Identification of hydroxyeicosatetraenoic acid components of schistosomal hemozoin [J].

Carter, Melissa D. ;

Harry, S. Reese ;

Wright, David W. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 363 (03) :867-872

[8]

Peroxisome Proliferator-Activated Receptor (PPAR): Balance for Survival in Parasitic Infections [J].

Chan, Marion M. ;

Evans, Kyle W. ;

Moore, Andrea R. ;

Fong, Dunne .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010,

[9]

Hepatic stellate cells in human schistosomiasis mansoni: A comparative immunohistochemical study with liver [J].

Chang, D ;

Ramalho, LNZ ;

Ramalho, FS ;

Martinelli, ALC ;

Zucoloto, S .

ACTA TROPICA, 2006, 97 (03) :318-323

[10]

Pioglitazone Suppresses Inflammation In Vivo in Murine Carotid Atherosclerosis Novel Detection by Dual-Target Fluorescence Molecular Imaging [J].

Chang, Kiyuk ;

Francis, Sanjeev A. ;

Aikawa, Elena ;

Figueiredo, Jose-Luiz ;

Kohler, Rainer H. ;

McCarthy, Jason R. ;

Weissleder, Ralph ;

Plutzky, Jorge ;

Jaffer, Farouc A. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2010, 30 (10) :1933-U150

← 1 2 3 4 5 6 →