Control of EGF receptor signaling by clathrin-mediated endocytosis

被引：815

作者：

Vieira, AV ^{[1
]}

Lamaze, C ^{[1
]}

Schmid, SL ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT CELL BIOL, LA JOLLA, CA 92037 USA

来源：

SCIENCE | 1996年 / 274卷 / 5295期

关键词：

D O I：

10.1126/science.274.5295.2086

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Epidermal growth factor receptor (EGFR) signaling was analyzed in mammalian cells conditionally defective for receptor-mediated endocytosis. EGF-dependent cell proliferation was enhanced in endocytosis-defective cells. However, early EGF-dependent signaling events were not uniformly up-regulated. A subset of signal transducers required the normal endocytic trafficking of EGFR for full activation. Thus, endocytic trafficking of activated EGFR plays a critical role not only in attenuating EGFR signaling but also in establishing and controlling specific signaling pathways.

引用

页码：2086 / 2089

页数：4

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