Bacterial and mammalian HMG-CoA reductases: related enzymes with distinct architectures

被引：40

作者：

Istvan, ES ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Howard Hughes Med Inst, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Microbiol, St Louis, MO 63110 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2001年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0959-440X(01)00276-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The committed step in the biosynthesis of isoprenoids is catalyzed by HMG-CoA reductase. Recently determined structures of the distantly related bacterial and mammalian HMG-CoA reductases have revealed two distinct classes of the protein with differently formed active sites and oligomeric states. An appreciation of the remarkable differences in the active site architecture may ultimately lead to the development of novel antibacterial agents.

引用

页码：746 / 751

页数：6

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