Acute repetitive transcranial magnetic stimulation reactivates dopaminergic system in lesion rats

被引：33

作者：

Funamizu, H

Ogiue-Ikeda, M

Mukai, H

Kawato, S

Ueno, S

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Biomed Engn, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Grad Sch Arts & Sci, Dept Biophys & Life Sci, Meguro Ku, Tokyo 1538902, Japan

来源：

NEUROSCIENCE LETTERS | 2005年 / 383卷 / 1-2期

关键词：

rTMS; MPTP; rearing; tyrosine hydroxylase (TH);

D O I：

10.1016/j.neulet.2005.04.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Repetitive transcranial magnetic stimulation (rTMS) offers potential benefit as a therapeutic treatment for neurological and psychiatric disorders. However, the mechanism underlying the therapeutic effects of rTMS is still unknown. In this study, we investigated the rescue effects of rTMS in the lesioned rats by administering the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). The rats received rTMS (10 trains of 25 pulses/s for 8 s) 48 h after MPTP injection, and tyrosine hydroxylase (TH) and NeuN expressions were investigated in the substantia nigra. The functional observational battery-hunched posture score for the MPTP-rTMS group was significantly lower and the number of rearing events was higher compared with the MPTP-sham group, these behavioral parameters revert to control levels. These results suggest that rTMS treatment reactivates the dopaminergic system in lesion rats. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：77 / 81

页数：5

共 20 条

[1] ESTIMATION OF NUCLEAR POPULATION FROM MICROTOME SECTIONS [J].