A critical appraisal of the phenomenon of aspirin resistance - A review

被引：16

作者：

Poulsen, TS

Kristensen, SR

Atar, D

Mickley, H

机构：

[1] Odense Univ Hosp, Dept Cardiol, DK-5000 Odense, Denmark

[2] Aarhus Univ Hosp, Aalborg Hosp, Cardiovasc Res Ctr, Dept Clin Biochem, Aalborg, Denmark

[3] Univ Oslo, Aker Univ Hosp, Div Cardiol, Oslo, Norway

来源：

CARDIOLOGY | 2005年 / 104卷 / 02期

关键词：

antiplatelet treatment; aspirin resistance; thromboxane A(2);

D O I：

10.1159/000086690

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aspirin is the mainstay antiplatelet treatment in patients with high risk of card iovascularatherothrombotic events, and its beneficial effect is documented in several clinical trials. Nevertheless, the effectiveness of aspirin has been questioned by the emergence of the concept of 'aspirin resistance' (AR). This phenomenon, although lacking a precise definition, covers the fact that some patients do not exhibit the expected platelet inhibition by use of various techniques for measuring platelet function. In this critical review, we evaluate the methods used for measuring AR. We will discuss the available data regarding the prevalence and the clinical importance of the phenomenon. Finally, the potential mechanisms underlying AIR are considered. Copyright (c) 2005 S. Karger AG, Basel.

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收藏

页码：83 / 91

页数：9

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