Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: A combined structural and resting-state functional MRI study

被引:323
作者
Bai, Feng [1 ,2 ]
Zhang, Zhijun [1 ,2 ]
Yu, Hui [1 ,2 ]
Shi, Yongmei [1 ,2 ]
Yuan, Yonggui [2 ]
Zhu, Wanlin [3 ,4 ]
Zhang, Xiangrong
Qian, Yun [1 ,2 ]
机构
[1] SE Univ, Affiliated ZhongDa Hosp, Dept Neurol, Nanjing 210009, Peoples R China
[2] SE Univ, Sch Clin Med, Nanjing 210009, Peoples R China
[3] Zhejiang Univ, Dept Math, Hangzhou 310027, Peoples R China
[4] Chinese Acad Sci, Inst Automat, Beijing 100875, Peoples R China
基金
中国国家自然科学基金;
关键词
mild cognitive impairment; default-mode; resting-state; voxel-based morphometry; low-frequency fluctuation;
D O I
10.1016/j.neulet.2008.04.021
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Resting-state functional magnetic resonance imaging (MRI), have revealed coactivation in a distributed network that characterizes the default-mode in the human brain. However, details from resting-state imaging in amnestic type mild cognitive impairment (aMCI) is poorly understand. Regional homogeneity, which characterizes low-frequency blood oxygenation level dependent fluctuation, after statistically controlling for the regional atrophy and age in resting-state, were examined and compared between the two groups. When regional atrophy was controlled, decreased regional homogeneity in posterior cingulate cortex and precuneus still remained significant in aMCI patients. In addition the aMCI subjects displayed several regions of increased homogeneity, typically in right inferior parietal lobule, right fusiform gyrus and bilateral putamen. The impairment of posterior cingulate and precuneus could be an important marker to distinguish aMCI from healthy aging in the resting-state. Moreover, the increased regional homogeneity changes would be consistent with compensation for damage to the medial temporal regions and limbic structures, perhaps by recruitment of alternative regions. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:111 / 115
页数:5
相关论文
共 43 条
[1]
Activity and connectivity of brain mood regulating circuit in depression: A functional magnetic resonance study [J].
Anand, A ;
Li, Y ;
Wang, Y ;
Wu, JW ;
Gao, SJ ;
Bukhari, L ;
Mathews, VP ;
Kalnin, A ;
Lowe, MJ .
BIOLOGICAL PSYCHIATRY, 2005, 57 (10) :1079-1088
[2]
Disruption of large-scale brain systems in advanced aging [J].
Andrews-Hanna, Jessica R. ;
Snyder, Abraham Z. ;
Vincent, Justin L. ;
Lustig, Cindy ;
Head, Denise ;
Raichle, Marcus E. ;
Buckner, Randy L. .
NEURON, 2007, 56 (05) :924-935
[3]
Voxel-based morphometry - The methods [J].
Ashburner, J ;
Friston, KJ .
NEUROIMAGE, 2000, 11 (06) :805-821
[4]
Unified segmentation [J].
Ashburner, J ;
Friston, KJ .
NEUROIMAGE, 2005, 26 (03) :839-851
[5]
Voxel-based mapping of brain hypometabolism in permanent amnesia with PET [J].
Aupée, AM ;
Desgranges, B ;
Eustache, F ;
Lalevée, C ;
de la Sayette, V ;
Viader, F ;
Baron, JC .
NEUROIMAGE, 2001, 13 (06) :1164-1173
[6]
Compensatory reallocation of brain resources supporting verbal episodic memory in Alzheimer's disease [J].
Becker, JT ;
Mintun, MA ;
Aleva, K ;
Wiseman, MB ;
Nichols, T ;
DeKosky, ST .
NEUROLOGY, 1996, 46 (03) :692-700
[7]
FUNCTIONAL CONNECTIVITY IN THE MOTOR CORTEX OF RESTING HUMAN BRAIN USING ECHO-PLANAR MRI [J].
BISWAL, B ;
YETKIN, FZ ;
HAUGHTON, VM ;
HYDE, JS .
MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (04) :537-541
[8]
Functional connectivity of the fusiform gyrus during a face-matching task in subjects with mild cognitive impairment [J].
Bokde, ALW ;
Lopez-Bayo, P ;
Meindl, T ;
Pechler, S ;
Born, C ;
Faltraco, F ;
Teipel, SJ ;
Möller, HJ ;
Hampel, H .
BRAIN, 2006, 129 :1113-1124
[9]
The contribution of voxel-based morphometry in staging patients with mild cognitive impairment [J].
Bozzali, M. ;
Filippi, M. ;
Magnani, G. ;
Cercignani, M. ;
Franceschi, M. ;
Schiatti, E. ;
Castiglioni, S. ;
Mossini, R. ;
Falautano, M. ;
Scotti, G. ;
Comi, G. ;
Falini, A. .
NEUROLOGY, 2006, 67 (03) :453-460
[10]
Abnormal neural activity in children with attention deficit hyperactivity disorder: a resting-state functional magnetic resonance imaging study [J].
Cao, Qingjiu ;
Zang, Yufeng ;
Sun, Li ;
Sui, Manqiu ;
Long, Xiangyu ;
Zou, Qihong ;
Wang, Yufeng .
NEUROREPORT, 2006, 17 (10) :1033-1036