Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water

被引:125
作者
Huang, KC
Yang, CC
Lee, KT
Chien, CT
机构
[1] Natl Taiwan Univ Hosp, Dept Med Res, Taipei, Taiwan
[2] Natl Taiwan Univ Hosp, Dept Family Med, Taipei, Taiwan
[3] Natl Taiwan Univ, Coll Med, Dept Family Med, Taipei 10018, Taiwan
[4] Natl Taiwan Univ, Coll Med, Dept Med Res, Taipei 10018, Taiwan
[5] Taipei Municipal Hoping Hosp, Taipei, Taiwan
[6] Wan Hwa Reg Hosp, Taipei, Taiwan
关键词
hemodialysis; electrolyzed reduced water; reactive oxygen species; end-stage renal diseases;
D O I
10.1046/j.1523-1755.2003.00118.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background. Increased oxidative stress in end-stage renal disease (ESRD) patients may oxidize macromolecules and consequently lead to cardiovascular events during chronic hemodialysis. Electrolyzed reduced water (ERW) with reactive oxygen species (ROS) scavenging ability may have a potential effect on reduction of hemodialysis-induced oxidative stress in ESRD patients. Methods. We developed a chemiluminescence emission spectrum and high-performance liquid chromatography analysis to assess the effect of ERW replacement on plasma ROS (H-2 O-2 and HOCl) scavenging activity and oxidized lipid or protein production in ESRD patients undergoing hemodialysis. Oxidized markers, dityrosine, methylguanidine, and phosphatidylcholine hydroperoxide, and inflammatory markers, interleukin 6 (IL-6), and C-reactive protein (CRP) were determined. Results. Although hemodialysis efficiently removes dityrosine and creatinine, hemodialysis increased oxidative stress, including phosphatidylcholine hydroperoxide, and methylguanidine. Hemodialysis reduced the plasma ROS scavenging activity, as shown by the augmented reference H-2 O-2 and HOCl counts (Rh-2 o(2) and Rhocl, respectively) and decreased antioxidative activity (expressed as total antioxidant status in this study). ERW administration diminished hemodialyis-enhanced Rh-2 o(2) and Rhocl, minimized oxidized and inflammatory markers (CRP and IL-6), and partly restored total antioxidant status during 1-month treatment. Conclusion. This study demonstrates that hemodialysis with ERW administration may efficiently increase the H-2 O-2 - and HOCl-dependent antioxidant defense and reduce H-2 O-2 - and HOCl-induced oxidative stress.
引用
收藏
页码:704 / 714
页数:11
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