AtCCS is a functional homolog of the yeast copper chaperone Ccs1/Lys7

被引：85

作者：

Abdel-Ghany, SE

Burkhead, JL

Gogolin, KA

Andrés-Colás, N

Bodecker, JR

Puig, S

Peñarrubia, L

Pilon, M

机构：

[1] Colorado State Univ, Dept Biol, Ft Collins, CO 80523 USA

[2] Univ Valencia, Fac Ciencias Biol, Dpto Bioquim & Biol Mol, Valencia 46100, Spain

来源：

FEBS LETTERS | 2005年 / 579卷 / 11期

关键词：

chloroplast; Cu/Zn superoxide dismutase; metallo chaperone; copper;

D O I：

10.1016/j.febslet.2005.03.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In plant chloroplasts two superoxide dismutase (SOD) activities occur, FeSOD and Cu/ZnSOD, with reciprocal regulation in response to copper availability. This system presents a unique model to study the regulation of metal-cofactor delivery to an organelle. The Arabidopsis thaliana gene AtCCS encodes a functional homolog to yeast Ccs1p/Lys7p, a copper chaperone for SOD. The AtCCS protein was localized to chloroplasts where it may supply copper to the stromal Cu/ZnSOD. AtCCS mRNA expression levels are upregulated in response to Cu-feeding and senescence. We propose that AtCCS expression is regulated to allow the most optimal use of Cu for photosynthesis. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2307 / 2312

页数：6

共 34 条

[1] ABDELGHANY S, 2005, IN PRESS PLANT CELL
[2] The water-water cycle in chloroplasts: Scavenging of active oxygens and dissipation of excess photons
Asada, K
[J]. ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY, 1999, 50 : 601 - 639
[3] SUPEROXIDE-DISMUTASE AND STRESS TOLERANCE
BOWLER, C
VANMONTAGU, M
INZE, D
[J]. ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY, 1992, 43 : 83 - 116
[4] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[5] Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase
Brown, NM
Torres, AS
Doan, PE
O'Halloran, TV
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (15) : 5518 - 5523
[6] The Arabidopsis thaliana CUTA gene encodes an evolutionarily conserved copper binding chloroplast protein
Burkhead, JL
Abdel-Ghany, SE
Morrill, JM
Pilon-Smits, EAH
Pilon, M
[J]. PLANT JOURNAL, 2003, 34 (06) : 856 - 867
[7] The copper chaperone for superoxide dismutase
Culotta, VC
Klomp, LWJ
Strain, J
Casareno, RLB
Krems, B
Gitlin, JD
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (38) : 23469 - 23472
[8] Oxygen-induced maturation of SOD1: a key role for disulfide formation by the copper chaperone CCS
Furukawa, Y
Torres, AS
O'Halloran, TV
[J]. EMBO JOURNAL, 2004, 23 (14) : 2872 - 2881
[9] Functional relationship of cytochrome c6 and plastocyanin in Arabidopsis
Gupta, R
He, ZY
Luan, S
[J]. NATURE, 2002, 417 (6888) : 567 - 571
[10] Intracellular copper routing: the role of copper chaperones
Harrison, MD
Jones, CE
Solioz, M
Dameron, CT
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (01) : 29 - 32

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