β-Lactam antibiotics, β-lactamases and bacterial resistance

被引：40

作者：

Kotra, LP ^{[1
]}

Mobashery, S ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

BULLETIN DE L INSTITUT PASTEUR | 1998年 / 96卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0020-2452(98)80009-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

beta-Lactams are the most prescribed antibacterials for the treatment of bacterial infections. Bacteria have developed mechanisms to resist the action of beta-lactam drugs, of which the catalytic function of beta-lactamase is the most important, These enzymes catalyse hydrolysis of beta-lactam antibiotics, whereby the drug is destroyed. This review offers a perspective on the function of these enzymes and their clinical implications.

引用

收藏

页码：139 / 150

页数：12

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