Alu insertion polymorphisms and the genetic structure of human populations from the Caucasus

被引:68
作者
Nasidze, I
Risch, GM
Robichaux, M
Sherry, ST
Batzer, MA
Stoneking, M
机构
[1] Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany
[2] Louisiana State Univ, Hlth Sci Ctr, Neurosci Ctr Excellence, Stanley S Scott Canc Ctr,Dept Biometry & Genet, New Orleans, LA 70112 USA
[3] Louisiana State Univ, Hlth Sci Ctr, Neurosci Ctr Excellence, Stanley S Scott Canc Ctr,Dept Biochem & Mol Biol, New Orleans, LA 70112 USA
[4] Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA
基金
美国国家科学基金会;
关键词
Alu insertion; polymorphisms; Caucasus populations;
D O I
10.1038/sj.ejhg.5200615
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
An analysis of 8 Alu insertion loci (ACE, TPA25, PV92, APO, FXIIIB, D1, A25, B65) has been carried out in six populations from the Caucasus, including Indo-European-speaking Armenians; Altaic-speaking Azerbaijanians; North Caucasian-speaking Cherkessians, Darginians, and Ingushians; and South Caucasian (Kartvelian)-speaking Georgians. The Caucasus populations exhibit low levels of within-population variation and high levels of between-population differentiation, with the average F-st value for the Caucasus of 0.113, which is almost as large as the F-st value of 0.157 for worldwide populations. Maximum likelihood tree and principal coordinate analyses both group the Caucasus populations with European populations. Neither geographic nor linguistic relationships appear to explain the genetic relationships of Caucasus populations. Instead, it appears as if they have been small and relatively isolated, and hence genetic drift has been the dominant influence on the genetic structure of Caucasus populations.
引用
收藏
页码:267 / 272
页数:6
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