Mouse models of advanced spontaneous metastasis for experimental therapeutics

被引：283

作者：

Francia, Giulio ^{[1
]}

Cruz-Munoz, William ^{[1
]}

Man, Shan ^{[1
]}

Xu, Ping ^{[1
]}

Kerbel, Robert S. ^{[1
]}

机构：

[1] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 02期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

BREAST-CANCER METASTASIS; MAMMARY-CARCINOMA METASTASIS; TUMOR-CELL-LINES; NUDE-MICE; IN-VIVO; DRUG DEVELOPMENT; METRONOMIC CYCLOPHOSPHAMIDE; ORTHOTOPIC TRANSPLANTATION; ANTIANGIOGENIC THERAPY; PANCREATIC-CANCER;

D O I：

10.1038/nrc3001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An enduring problem in cancer research is the failure to reproduce highly encouraging preclinical therapeutic findings using transplanted or spontaneous primary tumours in mice in clinical trials of patients with advanced metastatic disease. There are several reasons for this, including the failure to model established, visceral metastatic disease. We therefore developed various models of aggressive multi-organ spontaneous metastasis after surgical resection of orthotopically transplanted human tumour xenografts. In this Opinion article we provide a personal perspective summarizing the prospect of their increased clinical relevance. This includes the reduced efficacy of certain targeted anticancer drugs, the late emergence of spontaneous brain metastases and the clinical trial results evaluating a highly effective therapeutic strategy previously tested using such models.

引用

页码：135 / 141

页数：7

共 73 条

[1] Spectrum of breast cancer metastasis in BRCA1 mutation carriers:: highly increased incidence of brain metastases [J].

Albiges, L ;

André, F ;

Balleyguier, C ;

Gomez-Abuin, G ;

Chompret, A ;

Delaloge, S .

ANNALS OF ONCOLOGY, 2005, 16 (11) :1846-U3

[2] STUDIES OF MAMMARY-CARCINOMA METASTASIS IN A MOUSE MODEL SYSTEM .1. DERIVATION AND CHARACTERIZATION OF CELLS WITH DIFFERENT METASTATIC PROPERTIES DURING TUMOR PROGRESSION INVIVO [J].

BARNETT, SC ;

ECCLES, SA .

CLINICAL & EXPERIMENTAL METASTASIS, 1984, 2 (01) :15-36

[3] STUDIES OF MAMMARY-CARCINOMA METASTASIS IN A MOUSE MODEL SYSTEM .2. LECTIN BINDING-PROPERTIES OF CELLS IN RELATION TO THE INCIDENCE AND ORGAN DISTRIBUTION OF METASTASES [J].

BARNETT, SC ;

ECCLES, SA .

CLINICAL & EXPERIMENTAL METASTASIS, 1984, 2 (04) :297-310

[4] Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors [J].

Bergers, G ;

Song, S ;

Meyer-Morse, N ;

Bergsland, E ;

Hanahan, D .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (09) :1287-1295

[5] Genes that mediate breast cancer metastasis to the brain [J].

Bos, Paula D. ;

Zhang, Xiang H. -F. ;

Nadal, Cristina ;

Shu, Weiping ;

Gomis, Roger R. ;

Nguyen, Don X. ;

Minn, Andy J. ;

van de Vijver, Marc J. ;

Gerald, William L. ;

Foekens, John A. ;

Massague, Joan .

NATURE, 2009, 459 (7249) :1005-U137

[6] Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice [J].

Brodie, SG ;

Xu, XL ;

Qiao, WH ;

Li, WM ;

Cao, L ;

Deng, CX .

ONCOGENE, 2001, 20 (51) :7514-7523

[7] Phase III trial of bevacizumab (BEV) in the primary treatment of advanced epithelial ovarian cancer (EOC), primary peritoneal cancer (PPC), or fallopian tube cancer (FTC): A Gynecologic Oncology Group study [J].

Burger, R. A. ;

Brady, M. F. ;

Bookman, M. A. ;

Walker, J. L. ;

Homesley, H. D. ;

Fowler, J. ;

Monk, B. J. ;

Greer, B. E. ;

Boente, M. ;

Liang, S. X. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (18)

[8] The Vascular Basement Membrane as "Soil'' in Brain Metastasis [J].

Carbonell, W. Shawn ;

Ansorge, Olaf ;

Sibson, Nicola ;

Muschel, Ruth .

PLOS ONE, 2009, 4 (06)

[9] Development of a preclinical model of spontaneous human melanoma central nervous system metastasis [J].

Cruz-Munoz, William ;

Man, Shan ;

Xu, Ping ;

Kerbel, Robert S. .

CANCER RESEARCH, 2008, 68 (12) :4500-4505

[10] Effective Treatment of Advanced Human Melanoma Metastasis in Immunodeficient Mice Using Combination Metronomic Chemotherapy Regimens [J].

Cruz-Munoz, William ;

Man, Shan ;

Kerbel, Robert S. .

CLINICAL CANCER RESEARCH, 2009, 15 (15) :4867-4874

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