A novel functional translocator protein ligand for cancer imaging

被引：25

作者：

Bai, Mingfeng

Rone, Malena B.

Papadopoulos, Vassilios

Bornhop, Darryl J. ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Chem, VU Stn B 351822, Stevenson Ctr 7300, Nashville, TN 37235 USA

[2] Georgetown Univ, Med Ctr, Dept Biochem & Mol & Cellular Biol, Washington, DC 20057 USA

来源：

BIOCONJUGATE CHEMISTRY | 2007年 / 18卷 / 06期

关键词：

D O I：

10.1021/bc700251e

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The translocator protein (TSPO) is an attractive target for tumor imaging due to its up-regulation in numerous cancer cell types. Here, we report a series of functional TSPO ligands, n-TSPOmbb732, which can be conjugated to a variety of signaling moieties and are widely applicable in TSPO-targeted molecular imaging. Two fluorescent dye-labeled 6-TSPOmbb732 displayed nanomolar binding affinities to TSPO and were successfully imaged in vitro.

引用

收藏

页码：2018 / 2023

页数：6

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