The Role of Genetics in IBS

被引：118

作者：

Saito, Yuri A. ^{[1
]}

机构：

[1] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2011年 / 40卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Irritable bowel syndrome; Genetics; Gene; Complex genetic disease; IRRITABLE-BOWEL-SYNDROME; FUNCTIONAL GASTROINTESTINAL DISORDERS; SELF-REPORTED ABUSE; RECEPTOR GENE; RECTAL DISTENSION; PHYSICAL ABUSE; FAMILY-HISTORY; 5-HTT LPR; POLYMORPHISM; ASSOCIATION;

D O I：

10.1016/j.gtc.2010.12.011

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Irritable bowel syndrome (IBS) is a common disorder that has been shown to aggregate in families and to affect multiple generations, but not in a manner consistent with a major Mendelian effect. Relatives of an individual with IBS are 2 to 3 times as likely to have IBS, with both genders being affected. To date, more than 100 genetic variants in more than 60 genes from various pathways have been studied in a number of candidate gene studies, with several positive associations reported. These findings suggest that there may be distinct, as well as shared, molecular underpinnings for IBS and its subtypes.

引用

页码：45 / +

页数：25

共 83 条

[1]

Gastric suction at birth associated with long-term risk for functional intestinal disorders in later life [J].

Anand, KJS ;

Runeson, B ;

Jacobson, B .

JOURNAL OF PEDIATRICS, 2004, 144 (04) :449-454

[2]

Is there an association between GNβ3-C825T genotype and lower functional gastrointestinal disorders? [J].

Andresen, Viola ;

Camilleri, Michael ;

Kim, H. Jae ;

Stephens, Debra A. ;

Carlson, Paula J. ;

Talley, Nicholas J. ;

Saito, Yuri A. ;

Urrutia, Raul ;

Zinsmeister, Alan R. .

GASTROENTEROLOGY, 2006, 130 (07) :1985-1994

[3]

T-Helper 1, T-Helper 2, and T-Regulatory Cytokines Gene Polymorphisms in Irritable Bowel Syndrome [J].

Barkhordari, Elham ;

Rezaei, Nima ;

Mahmoudi, Mahdi ;

Larki, Pegah ;

Ahmadi-Ashtiani, Hamid Reza ;

Ansaripour, Bita ;

Alighardashi, Maryam ;

Bashashati, Mohammad ;

Amirzargar, Ali Akbar ;

Ebrahimi-Daryani, Naser .

INFLAMMATION, 2010, 33 (05) :281-286

[4]

Proinflammatory Cytokine Gene Polymorphisms in Irritable Bowel Syndrome [J].

Barkhordari, Elham ;

Rezaei, Nima ;

Ansaripour, Bita ;

Larki, Pegah ;

Alighardashi, Maryam ;

Ahmadi-Ashtiani, Hamid Reza ;

Mahmoudi, Mahdi ;

Keramati, Mohammad-Reza ;

Habibollahi, Peiman ;

Bashashati, Mohammad ;

Ebrahimi-Daryani, Naser ;

Amirzargar, Ali Akbar .

JOURNAL OF CLINICAL IMMUNOLOGY, 2010, 30 (01) :74-79

[5]

New insights in the etiology and pathophysiology of irritable bowel syndrome: Contribution of neonatal stress models [J].

Barreau, Frederick ;

Ferrier, Laurent ;

Fioramonti, Jean ;

Bueno, Lionel .

PEDIATRIC RESEARCH, 2007, 62 (03) :240-245

[6]

A SIMPLE SCORE FOR THE IDENTIFICATION OF PATIENTS AT HIGH-RISK OF ORGANIC DISEASES OF THE COLON IN THE FAMILY DOCTOR CONSULTING ROOM [J].

BELLENTANI, S ;

BALDONI, P ;

PETRELLA, S ;

TATA, C ;

ARMOCIDA, C ;

MARCHEGIANO, P ;

SACCOCCIO, G ;

MANENTI, F .

FAMILY PRACTICE, 1990, 7 (04) :307-312

[7]

Familial Aggregation in Children Affected by Functional Gastrointestinal Disorders [J].

Buonavolonta, R. ;

Coccorullo, P. ;

Turco, R. ;

Boccia, G. ;

Greco, L. ;

Staiano, A. .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2010, 50 (05) :500-505

[8]

Candidate genes and sensory functions in health and irritable bowel syndrome [J].

Camilleri, Michael ;

Busciglio, Irene ;

Carlson, Paula ;

McKinzie, Sanna ;

Burton, Duane ;

Baxter, Kari ;

Ryks, Michael ;

Zinsmeister, Alan R. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2008, 295 (02) :G219-G225

[9]

Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation [J].

Camilleri, Michael ;

Carlson, Paula ;

McKinzie, Sanna ;

Grudell, April ;

Busciglio, Irene ;

Burton, Duane ;

Baxter, Kari ;

Ryks, Michael ;

Zinsmeister, Alan R. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2008, 294 (01) :G13-G19

[10]

Neuropeptide S Receptor Induces Neuropeptide Expression and Associates With Intermediate Phenotypes of Functional Gastrointestinal Disorders [J].

Camilleri, Michael ;

Carlson, Paula ;

Zinsmeister, Alan R. ;

McKinzie, Sanna ;

Busciglio, Irene ;

Burton, Duane ;

Zucchelli, Marco ;

D'Amato, Mauro .

GASTROENTEROLOGY, 2010, 138 (01) :98-107

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