Suppressive effects of Anoectochilus formosanus extract on osteoclast formation in vitro and bone resorption in vivo

被引：19

作者：

Masuda, Kikuko ^{[1
]}

Ikeuchi, Mayumi ^{[1
]}

Koyama, Tomoyuki ^{[1
]}

Yamaguchi, Kohji ^{[1
]}

Woo, Je-Tae ^{[2
]}

Nishimura, Tomio ^{[3
]}

Yazawa, Kazunaga ^{[1
]}

机构：

[1] Tokyo Univ Marine Sci & Technol, Grad Sch Marine Sci & Technol, Lab Nutraceut & Funct Foods Sci, Minato Ku, Tokyo 1088477, Japan

[2] Chubu Univ, Dept Biol Chem, Aichi, Japan

[3] Akatsuka Bot Garden, Tsu, Mie, Japan

来源：

JOURNAL OF BONE AND MINERAL METABOLISM | 2008年 / 26卷 / 02期

关键词：

Anoectochilus formosanus; osteoporosis; osteoclast; bone resorption; RANKL;

D O I：

10.1007/s00774-007-0810-8

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Anoectochilus formosanus, a plant native to Taiwan, is used as a folk medicine. It was found that oral administration of A. formosanus extract (AFE) (500 mg/kg) for 4 weeks suppressed bone weight loss and trabecular bone loss in ovariectomized mice, an experimental model of osteoporosis. Although AFE at 12.5 and 25 mu g/ml inhibited osteoclast formation in co-culture of osteoblasts and bone marrow cells, AFE did not inhibit the formation of osteoclast progenitor cells and preosteoclast cells in bone marrow cells and RAW264 cells. However, AFE (at 12.5 and 25 mu g/ml) decreased RANKL expression. These results suggested that AFE might suppress the bone loss caused by estrogen deficiency through suppression of RANKL expression required for osteoclast formation.

引用

页码：123 / 129

页数：7

共 23 条

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[2]

MOLECULAR MECHANISMS OF BONE-RESORPTION BY THE OSTEOCLAST [J].