The involvement of astrocytes and kynurenine pathway in Alzheimer's disease

被引：41

作者：

Ting, Ka Ka ^{[1
,3
]}

Brew, Bruce ^{[2
]}

Guillemin, Gilles ^{[1
,3
]}

机构：

[1] St Vincents Hosp, Ctr Immunol, Sydney, NSW 2010, Australia

[2] St Vincents Hosp, Dept Neurol, Sydney, NSW 2010, Australia

[3] Univ New S Wales, Dept Pharmacol, Sydney, NSW 2052, Australia

来源：

NEUROTOXICITY RESEARCH | 2007年 / 12卷 / 04期

基金：

英国医学研究理事会;

关键词：

astrocyte; kynurenine pathway; Alzheimer's disease; neuroinflammation;

D O I：

10.1007/BF03033908

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The kynurenine pathway (KP) and several of its neuroactive products, especially quinolinic acid (QUIN), are considered to be involved in the neuropathogenesis of Alzheimer's disease (AD). There is growing evidence suggesting that astrocytes play a critical role in the regulation of the excitotoxicity and inflammatory processes that occur during the evolution of AD. This review focuses on the role of astrocytes through their relation with the KP to the different features associated with AD including cytokine, chemokine and, adhesion molecule production, cytoskeletal changes, astrogliosis, excitotoxicity, apoptosis and neurodegeneration.

引用

页码：247 / 262

页数：16

共 145 条

[1] Inflammation and Alzheimer's disease [J].

Akiyama, H ;

Barger, S ;

Barnum, S ;

Bradt, B ;

Bauer, J ;

Cole, GM ;

Cooper, NR ;

Eikelenboom, P ;

Emmerling, M ;

Fiebich, BL ;

Finch, CE ;

Frautschy, S ;

Griffin, WST ;

Hampel, H ;

Hull, M ;

Landreth, G ;

Lue, LF ;

Mrak, R ;

Mackenzie, IR ;

McGeer, PL ;

O'Banion, MK ;

Pachter, J ;

Pasinetti, G ;

Plata-Salaman, C ;

Rogers, J ;

Rydel, R ;

Shen, Y ;

Streit, W ;

Strohmeyer, R ;

Tooyoma, I ;

Van Muiswinkel, FL ;

Veerhuis, R ;

Walker, D ;

Webster, S ;

Wegrzyniak, B ;

Wenk, G ;

Wyss-Coray, T .

NEUROBIOLOGY OF AGING, 2000, 21 (03) :383-421

[2]

Anderson CM, 2000, GLIA, V32, P1

[3] Immune and inflammatory responses in the CNS: modulation by astrocytes [J].

Aschner, M .

TOXICOLOGY LETTERS, 1998, 103 :283-287

[4]

Aschner M, 1998, NEUROTOXICOLOGY, V19, P269

[5] Block of glutamate-glutamine cycle between astrocytes and neurons inhibits epileptiform activity in hippocampus [J].

Bacci, A ;

Sancini, G ;

Verderio, C ;

Armano, S ;

Pravettoni, E ;

Fesce, R ;

Franceschetti, S ;

Matteoli, M .

JOURNAL OF NEUROPHYSIOLOGY, 2002, 88 (05) :2302-2310

[6] The blood-brain barrier: an overview - Structure, regulation, and clinical implications [J].

Ballabh, P ;

Braun, A ;

Nedergaard, M .

NEUROBIOLOGY OF DISEASE, 2004, 16 (01) :1-13

[7] Kynurenine metabolism in Alzheimer's disease [J].

Baran, H ;

Jellinger, K ;

Deecke, L .

JOURNAL OF NEURAL TRANSMISSION, 1999, 106 (02) :165-181

[8] KYNURENINE PATHWAY MEASUREMENTS IN HUNTINGTONS-DISEASE STRIATUM - EVIDENCE FOR REDUCED FORMATION OF KYNURENIC ACID [J].

BEAL, MF ;

MATSON, WR ;

SWARTZ, KJ ;

GAMACHE, PH ;

BIRD, ED .

JOURNAL OF NEUROCHEMISTRY, 1990, 55 (04) :1327-1339

[9] THE PREFERRED ROUTE OF KYNURENINE METABOLISM IN THE RAT [J].

BENDER, DA ;

MCCREANOR, GM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1982, 717 (01) :56-60

[10] PICOLINIC-ACID BLOCKS THE NEUROTOXIC BUT NOT THE NEUROEXCITANT PROPERTIES OF QUINOLINIC ACID IN THE RAT-BRAIN - EVIDENCE FROM TURNING BEHAVIOR AND TYROSINE-HYDROXYLASE IMMUNOHISTOCHEMISTRY [J].

BENINGER, RJ ;

COLTON, AM ;

INGLES, JL ;

JHAMANDAS, K ;

BOEGMAN, RJ .

NEUROSCIENCE, 1994, 61 (03) :603-612

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