STAT family of transcription factors in cytokine-mediated biological responses

被引：300

作者：

Takeda, K

Akira, S

机构：

[1] Osaka Univ, Microbial Dis Res Inst, Dept Hosp Def, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Japan Sci & Technol Corp, CREST, Suita, Osaka 5650871, Japan

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2000年 / 11卷 / 03期

关键词：

cytokine; signal transduction; STAT; knockout mice;

D O I：

10.1016/S1359-6101(00)00005-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

STAT (signal transducers and activators of transcription) family, consisting of seven members, is involved in cytokine signal transduction. Biologic;ll roles of each STAT family protein have now been elucidated through studies of gene targeted mice. Stat1 knockout mice are defective in interferon-mediated functions. Stat4 and Stat6 knockout mice show defective responses to IL-12. and IL-4, respectively. Analyses of Stat5a and Stat5b knockout mice reveal important roles in prolactin-mediated mammary gland development and growth hormone-mediated induction of sexual dimorphism, respectively. Conditional knockout study of Stat3 demonstrates its critical roles in cytokine-mediated functions in several tissues, including T cells, macrophages, skin, and mammary gland. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：199 / 207

页数：9

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