Post-translational modifications in Plasmodium: More than you think!

被引：39

作者：

Chung, Duk-Won Doug ^{[1
]}

Ponts, Nadia ^{[1
]}

Cervantes, Serena ^{[1
]}

Le Roch, Karine G. ^{[1
]}

机构：

[1] Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2009年 / 168卷 / 02期

关键词：

Plasmodium; Post-translational modification; Kinases; Proteases; Ubiquitin system; Life-cycle regulation; HUMAN MALARIA PARASITE; PROTEIN SERINE/THREONINE PHOSPHATASE; NITRIC-OXIDE SYNTHASE; B-LIKE ENZYME; GENE-EXPRESSION; HOST-CELL; IN-VITRO; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORS; FUNCTIONAL-CHARACTERIZATION; HISTONE ACETYLTRANSFERASE;

D O I：

10.1016/j.molbiopara.2009.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Recent evidences indicate that transcription in Plasmodium may be hard-wired and rigid, deviating from the classical model of transcriptional gene regulation Thus. it is important that other regulatory pathways be investigated as a comprehensive effort to curb the deadly malarial parasite. Research in post-translational modifications in Plasmodium is an emerging field that may provide new venues for drug discovery and potential new insights into how parasitic protozoans regulate their life cycle Here, we discuss the recent findings of post-translational modifications in Plasmodium Published by Elsevier B V

引用

页码：123 / 134

页数：12

共 173 条

[1]

Induction of nitric oxide synthase and activation of signaling proteins in Anopheles mosquitoes by the malaria pigment, hemozoin [J].

Akman-Anderson, Leyla ;

Olivier, Martin ;

Luckhart, Shirley .

INFECTION AND IMMUNITY, 2007, 75 (08) :4012-4019

[2]

A malarial cysteine protease is necessary for Plasmodium sporozoite egress from oocysts [J].

Aly, ASI ;

Matuschewski, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (02) :225-230

[3]

A genomic perspective of protein kinases in Plasmodium falciparum [J].

Anamika ;

Srinivasan, N ;

Krupa, A .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2005, 58 (01) :180-189

[4]

Targeting Histone Deacetylase Inhibitors for Anti-Malarial Therapy [J].

Andrews, Katherine T. ;

Tran, Thanh N. ;

Wheatley, Nicole C. ;

Fairlie, David P. .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2009, 9 (03) :292-308

[5]

Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum [J].

Arastu-Kapur, Shirin ;

Ponder, Elizabeth L. ;

Fonovic, Ursa Pecar ;

Yeoh, Sharon ;

Yuan, Fang ;

Fonovic, Marko ;

Grainger, Munira ;

Phillips, Carolyn I. ;

Powers, James C. ;

Bogyo, Matthew .

NATURE CHEMICAL BIOLOGY, 2008, 4 (03) :203-213

[6]

Proteases and protease inhibitors: a balance of activities in host-pathogen interaction [J].

Armstrong, Peter B. .

IMMUNOBIOLOGY, 2006, 211 (04) :263-281

[7]

The immunogenic properties of protozoan glycosylphosphatidylinositols in the mosquito Anopheles gambiae [J].

Arrighi, Romanico B. G. ;

Debierre-Grockiege, Francoise ;

Schwarz, Ralph T. ;

Faye, Ingrid .

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2009, 33 (02) :216-223

[8]

Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum [J].

Artavanis-Tsakonas, Katerina ;

Misaghi, Shahram ;

Comeaux, Christy A. ;

Catic, Andre ;

Spooner, Eric ;

Duraisingh, Manoj T. ;

Ploegh, Hidde L. .

MOLECULAR MICROBIOLOGY, 2006, 61 (05) :1187-1195

[9]

Palmitoylation cycles and regulation of protein function (Review) [J].

Baekkeskov, Steinnunn ;

Kanaani, Jamil .

MOLECULAR MEMBRANE BIOLOGY, 2009, 26 (1-2) :42-54

[10]

Two Plasmodium rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malaria [J].

Baker, Rosanna P. ;

Wijetilaka, Ruvini ;

Urban, Sinisa .

PLOS PATHOGENS, 2006, 2 (10) :922-932

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