In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae)

被引：97

作者：

da Silva Filho, A. A. ^{[1
]}

Resende, D. O. ^{[1
]}

Fukui, M. J. ^{[1
]}

Santos, F. F. ^{[1
]}

Pauletti, P. M. ^{[1
]}

Cunha, W. R. ^{[1
]}

Silva, M. L. A. ^{[1
]}

Gregorio, L. E. ^{[2
]}

Bastos, J. K. ^{[2
]}

Nanayakkara, N. P. D. ^{[3
]}

机构：

[1] Univ Franca, Lab Prod Nat, Nucleo Pesquisa Ciencias Exatas & Tecnol, BR-14404600 Franca, SP, Brazil

[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil

[3] Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA

来源：

FITOTERAPIA | 2009年 / 80卷 / 08期

基金：

巴西圣保罗研究基金会;

关键词：

Baccharis dracunculifolia; Brazilian green propolis; Leishmania donovani; Plasmodium falciparum; Ursolic acid; Hautriwaic acid lactone; BRAZILIAN GREEN PROPOLIS; TETRAHYDROFURAN LIGNANS; NECTANDRA-MEGAPOTAMICA; DERIVATIVES; DITERPENES; EXTRACTS; VIVO;

D O I：

10.1016/j.fitote.2009.06.007

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Baccharis dracunculifolia (Asteraceae), the most important plant source of the Brazilian green propolis (GPE), displayed in vitro activity against Leishmania donovani. with an IC50 value of 45 mu g/mL. while GPE presented an IC50 value of 49 mu g/mL Among the isolated compounds of B. dracunculifolia, ursolic acid, and hautriwaic acid lactone showed IC50 values of 3.7 mu g/mL and 7.0 mu g/mL, respectively. Uvaol, acacetin, and ermanin displayed moderate antileishmanial activity. Regarding the antiplasmodial assay against Plasmodium falciparum, BdE and GPE gave similar IC50 values (about 20 mu g/mL), while Hautriwaic acid lactone led to an IC50 value of 0.8 mu g/mL (D6 clone). (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：478 / 482

页数：5

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