Early gene expression in the rat cortex after experimental traumatic brain injury and hypotension

被引：25

作者：

Awasthi, D

Kutz, SC

Beuerman, R

Nguyen, D

Carey, ME

Zeiller, S

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Dept Neurosurg, New Orleans, LA 70112 USA

[2] Louisiana State Univ, Sch Med, Neurosci Ctr Excellence, Ctr Eye, New Orleans, LA 70112 USA

[3] Jefferson Med Coll, Dept Neurosurg, Philadelphia, PA USA

来源：

NEUROSCIENCE LETTERS | 2003年 / 345卷 / 01期

关键词：

experimental; gene expression; hypotension; rats; traumatic brain injury;

D O I：

10.1016/S0304-3940(03)00497-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

To determine c-fos and egr-1 mRNA levels in the rat cortex after traumatic brain injury (TBI) and TBI plus hemorrhagic hypotension (HH). Sprague-Dawley rats were subjected to TBI. HH was induced by removing 5 ml of blood from the jugular vein for a duration of 20 min. Cortical tissue was harvested at 0 and 120 min, and mRNA levels of the immediate early genes c-fos, egr-1 were obtained. Rats that sustained TBI alone had increased c-fos and egr-1 mRNA expression at 120 min that was significant. Additionally, c-fos mRNA levels after TBI alone were significantly higher than c-fos mRNA levels after TBI + HH at 120 min. Levels of egr-1 mRNA after TBI alone at 120 min were not significantly higher than egr-1 mRNA levels after TBI + HH at 120 min. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：29 / 32

页数：4

共 16 条

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