Periodontitis and cardiovascular diseases

被引：36

作者：

Suzuki, Jun-ichi ^{[1
]}

Aoyama, Norio ^{[2
,3
]}

Ogawa, Masahito ^{[1
]}

Hirata, Yasunobu ^{[1
]}

Izumi, Yuichi ^{[2
,3
]}

Nagai, Ryozo ^{[5
]}

Isobe, Mitsuaki ^{[4
]}

机构：

[1] Univ Tokyo, Dept Adv Clin Sci & Therapeut, Bunkyo Ku, Tokyo 1138655, Japan

[2] Tokyo Med & Dent Univ, Dept Periodontol, Tokyo, Japan

[3] Tokyo Med & Dent Univ, GCOE Program, Tokyo, Japan

[4] Tokyo Med & Dent Univ, Dept Cardiovasc Med, Tokyo, Japan

[5] Univ Tokyo, Dept Cardiovasc Med, Tokyo 1138655, Japan

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2010年 / 14卷 / 10期

关键词：

aorta; bacteria; cytokine; inflammation; periodontitis; ABDOMINAL AORTIC-ANEURYSMS; CORONARY-HEART-DISEASE; VITAMIN-D; MATRIX METALLOPROTEINASES; BUERGER-DISEASE; OLDER-ADULTS; RISK-FACTORS; D DEFICIENCY; ATHEROSCLEROSIS; EPIDEMIOLOGY;

D O I：

10.1517/14728222.2010.511616

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Periodontitis is characterized by gingival inflammation and periodontopathic bacteria generate immunological inflammatory responses. Recent epidemiological reports suggest that periodontitis is one of the key risk factors for the onset of cardiovascular diseases. Several studies reported that periodontal bacteria in cardiovascular specimens were frequently detected. We revealed that patients with acute coronary syndrome showed significantly higher serum IgG titers to a strain of periodontopathic bacteria compared with patients with chronic coronary disease. Periodontopathic bacteria were also present in a high percentage of specimens of diseased arteries from patients with Buerger disease or abdominal aortic aneurysm. Although periodontopathic bacteria may play a role in the development of cardiovascular diseases, the influence of these bacteria on the disease has not yet been proven. In this article, we review the relationship between periodontopathic pathogens and cardiovascular diseases to conduct further clinical and experimental investigations in near future.

引用

页码：1023 / 1027

页数：5

共 48 条

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Risk factors for abdominal aortic aneurysms in older adults enrolled in the cardiovascular health study [J].