μ-Opioid receptor-knockout mice:: the role of μ-opioid receptor in gastrointestinal transit

被引：89

作者：

Roy, S ^{[1
]}

Liu, HC ^{[1
]}

Loh, HH ^{[1
]}

机构：

[1] Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 56卷 / 1-2期

关键词：

knockout; mu-opioid receptor; morphine; gastrointestinal motility;

D O I：

10.1016/S0169-328X(98)00051-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of mu-opioid receptor in gastrointestinal transit was investigated using mu-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a mu-opioid receptor mediated function. In addition, we show that neither delta nor kappa receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (+/-) and wild type (+/+) animals. (C) 1998 Elsevier Science B.V.

引用

页码：281 / 283

页数：3

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