Influence of Nucleated Cell Dose on Overall Survival of Unrelated Cord Blood Transplantation for Patients with Severe Acquired Aplastic Anemia: A Study by Eurocord and the Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation

被引：82

作者：

de Latour, Regis Peffault ^{[1
]}

Purtill, Duncan

Ruggeri, Annalisa

Sanz, Guillermo ^{[2
]}

Michel, Gerard ^{[3
]}

Gandemer, Virginie ^{[4
]}

Maury, Sebastien ^{[5
]}

Kurtzberg, Joanne ^{[6
]}

Bonfim, Carmen ^{[7
]}

Aljurf, Mahmoud

Gluckman, Eliane

Socie, Gerard ^{[1
]}

Passweg, Jakob ^{[8
]}

Rocha, Vanderson ^{[1
]}

机构：

[1] Hop St Louis, Serv Hematol Greffe, Bone Marrow Transplant Unit, F-75010 Paris, France

[2] Hosp Univ La Fe, Dept Hematol, Valencia, Spain

[3] La Timone Hosp, Dept Hematol, Marseille, France

[4] Dept OncoPediat, Rennes, France

[5] Henri Mondor Hosp, Dept Hematol, Creteil, France

[6] Duke Univ, Med Ctr, Dept Pediat, Div Blood & Marrow Transplantat, Durham, NC 27710 USA

[7] Univ Fed Parana, BR-80060000 Curitiba, Parana, Brazil

[8] Geneve Univ Hosp, Geneva, Switzerland

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2011年 / 17卷 / 01期

关键词：

Acquired bone marrow failure; Alternative donor transplant; ALTERNATIVE DONOR TRANSPLANTS; ANTITHYMOCYTE GLOBULIN; BONE-MARROW; ADULT PATIENTS; PREEMPTIVE RITUXIMAB; FLUDARABINE; OUTCOMES; GRAFT; CYCLOPHOSPHAMIDE; CYCLOSPORINE;

D O I：

10.1016/j.bbmt.2010.06.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Information is scarce on outcomes after unrelated cord blood transplantation (UCBT) for patients with severe aplastic anemia (SAA). We retrospectively analyzed 71 patients (median age, 13 years; 28 adults) with SAA (9 with paroxysmal nocturnal hemoglobinuria [PNH]) who received a single-unit (n = 57; 79%) or double-unit UCBT (n = 14; 19%) in 32 centers between 1996 and 2009. A reduced-intensity conditioning regimen was provided in 68% of the patients. The cumulative incidence (Cl) of neutrophil recovery was 51% +/- 6% at day 60, with significantly better engraftment seen in recipients of higher prefreezing total nucleated cell (TNC) dose (>3.9 10(7)/kg; hazard ratio [HR], 1.5; P = .05). The Cl of platelet engraftment at day 180 posttransplantation was 37% +/- 7%, that of grade II-IV acute GVHD was 20% +/- 5%, and that of chronic GVHD at 3 years was 18% +/- 5%. At a median follow-up of 35 months (range, 3-83 months), the estimated probability of 3-year overall survival (OS) was 38% +/- 6%. Significantly improved OS was seen in recipients of >3.9 10(7) TNCs/kg prefreezing (45%, compared with 18% for recipients of <= 3.9 10(7) TNC/kg; HR, 0.4; P = .007). These results highlight the fundamental role of cell dose for both engraftment and OS in patients with SAA undergoing UCBT. Biol Blood Marrow Transplant 17: 78-85 (2011) (C) 2011 American Society for Blood and Marrow Transplantation

引用

页码：78 / 85

页数：8

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