Allosterism at muscarinic receptors: Ligands and mechanisms

被引：88

作者：

Birdsall, NJM

Lazareno, S

机构：

[1] Natl Inst Med Res, Div Phys Biochem, London NW7 1AA, England

[2] MRC Technol, London NW7 1AA, England

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2005年 / 5卷 / 06期

基金：

英国医学研究理事会;

关键词：

muscarinic receptors; allosterism; cooperativity; enhancers; receptor models; structure-activity relationships; interaction studies; receptor subtype selectivity;

D O I：

10.2174/1389557054023251

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The evaluation of allosteric ligands at muscarinic receptors is discussed in terms of the ability of the experimental data to be interpreted by the allosteric ternary complex model. The compilation of useful SAR information of allosteric ligands is not simple, especially for muscarinic receptors, where there are multiple allosteric sites and complex interactions.

引用

页码：523 / 543

页数：21

共 190 条

[1]

[Anonymous], ARCH GES PHYSL

[2] COMPARISON OF AFFINITY CONSTANTS FOR MUSCARINE-SENSITIVE ACETYLCHOLINE RECEPTORS IN GUINEA-PIG ATRIAL PACEMAKER CELLS AT 29 DEGREESC AND IN ILEUM AT 29 DEGREESC AND 37 DEGREESC [J].