Solid-state NMR spectroscopy in pharmaceutical research and analysis

被引：123

作者：

Berendt, Robert T.

Sperger, Diana M.

Isbester, Paul K.

Munson, Eric J.

机构：

[1] Univ Kansas, Dept Pharmaceut Chem, Lawrence, KS 66047 USA

[2] Albany Mol Res Inc, Analyt Qual Serv, Albany, NY 12212 USA

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2006年 / 25卷 / 10期

基金：

美国国家科学基金会;

关键词：

dosage form; excipient; pharmaceutical analysis; polymorph; solid-state NMR spectroscopy;

D O I：

10.1016/j.trac.2006.07.006

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

in this review, we discuss the motivation for using solid-state NMR (SSNMR) spectroscopy to study pharmaceutical solids, and then give an overview of the information obtained through SSNMR experiments. in addition, we explain the basics of SSNMR spectroscopy and describe several applications to the pharmaceutical field. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：977 / 984

页数：8

共 39 条

[1]

Abraham R.J., 1988, INTRO NMR SPECTROSCO

[2]

Alderman DW, 1998, MOL PHYS, V95, P1113, DOI 10.1080/00268979809483243

[3] Structural and dynamic aspects of hydrogen-bonded complexes and inclusion compounds containing α,ω-dicyanoalkanes and urea, investigated by solid-state 13C and 2H NMR techniques [J].