Decreased perfusion in young alcohol-dependent women as compared with age-matched controls

被引：28

作者：

Clark, Camellia P. ^{[1
]}

Brown, Gregory G. ^{[1
]}

Eyler, Lisa T. ^{[1
]}

Drummond, Sean P. A. ^{[1
]}

Braun, Deborah R. ^{[1
]}

Tapert, Susan F. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Psychiat 9151B, VA San Diego Healthcare Syst, La Jolla, CA 92093 USA

来源：

AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE | 2007年 / 33卷 / 01期

关键词：

alcohol abuse; alcoholism; perfusion magnetic resonance imaging;

D O I：

10.1080/00952990601082605

中图分类号：

B849 [应用心理学];

学科分类号：

040203 [应用心理学];

摘要：

Aim: To use the superior spatial resolution of magnetic resonance imaging (MRI) to examine differences in cerebral perfusion between young alcohol dependent and normal women. Methods: Eight alcohol dependent women and 8 controls (all ages 18-25) received single-slice resting perfusion-weighted MRI (directly proportional to brain blood flow), with slices located above the corpus callosum. Results: Alcohol-dependent women had decreased perfusion in prefrontal and left parietal regions. Conclusions: Reduced perfusion has not previously been reported in young, physically healthy alcohol dependent females, yet is consistent with previously reported decreased cerebral activity in alcohol dependence.

引用

页码：13 / 19

页数：7

共 16 条

[1]

BOLD and perfusion response to finger-thumb apposition after acetazolamide administration: Differential relationship to global perfusion [J].