The Leading Sense: Supramodal Control of Neurophysiological Context by Attention

被引:295
作者
Lakatos, Peter [1 ,3 ]
O'Connell, Monica N. [1 ]
Barczak, Annamaria [1 ,2 ]
Mills, Aimee [1 ]
Javitt, Daniel C. [1 ,3 ]
Schroeder, Charles E. [1 ,4 ]
机构
[1] Nathan S Kline Inst Psychiat Res, Cognit Neurosci & Schizophrenia Program, Orangeburg, NY 10962 USA
[2] NYU, Sch Med, Dept Physiol & Neurosci, New York, NY 10016 USA
[3] NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA
[4] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA
关键词
THALAMIC RETICULAR NUCLEUS; SUPERIOR TEMPORAL SULCUS; NEURONS IN-VIVO; AUDITORY-CORTEX; MULTISENSORY CONVERGENCE; AUDIOVISUAL INTEGRATION; THETA-OSCILLATIONS; PREFRONTAL CORTEX; DORSAL THALAMUS; NEURAL DYNAMICS;
D O I
10.1016/j.neuron.2009.10.014
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Attending to a stimulus enhances its neuronal representation, even at the level of primary sensory cortex. Cross-modal modulation can similarly enhance a neuronal representation, and this process can also operate at the primary cortical level. Phase reset of ongoing neuronal oscillatory activity has been shown to be an important element of the underlying modulation of local cortical excitability in both cases. We investigated the influence of attention on oscillatory phase reset in primary auditory and visual cortices of macaques performing an intermodal selective attention task. In addition to responses "driven" by preferred modality stimuli, we noted that both preferred and nonpreferred modality stimuli could "modulate" local cortical excitability by phase reset of ongoing oscillatory activity, and that this effect was linked to their being attended. These findings outline a supramodal mechanism by which attention can control neurophysiological context, thus determining the representation of specific sensory content in primary sensory cortex.
引用
收藏
页码:419 / 430
页数:12
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