pH-driven conformational switch of "i-motif'' DNA for the reversible assembly of gold nanoparticles

被引:120
作者
Sharma, Jaswinder
Chhabra, Rahul
Yan, Hao
Liu, Yan [1 ]
机构
[1] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA
[2] Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA
关键词
D O I
10.1039/b612707j
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Herein we demonstrate that gold nanoparticles conjugated to "i-motif'' DNA behave like a pH dependent switch that undergoes reversible aggregations which can be easily visualized by the naked eye.
引用
收藏
页码:477 / 479
页数:3
相关论文
共 26 条
[1]   All-optical nanoscale pH meter [J].
Bishnoi, Sandra W. ;
Rozell, Christopher J. ;
Levin, Carly S. ;
Gheith, Muhammed K. ;
Johnson, Bruce R. ;
Johnson, Don H. ;
Halas, Naomi J. .
NANO LETTERS, 2006, 6 (08) :1687-1692
[2]   Gold nanoparticles as a colorimetric sensor for protein conformational changes [J].
Chah, S ;
Hammond, MR ;
Zare, RN .
CHEMISTRY & BIOLOGY, 2005, 12 (03) :323-328
[3]   A fluorescence-based method for determining the surface coverage and hybridization efficiency of thiol-capped oligonucleotides bound to gold thin films and nanoparticles [J].
Demers, LM ;
Mirkin, CA ;
Mucic, RC ;
Reynolds, RA ;
Letsinger, RL ;
Elghanian, R ;
Viswanadham, G .
ANALYTICAL CHEMISTRY, 2000, 72 (22) :5535-5541
[4]   Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles [J].
Elghanian, R ;
Storhoff, JJ ;
Mucic, RC ;
Letsinger, RL ;
Mirkin, CA .
SCIENCE, 1997, 277 (5329) :1078-1081
[5]   The i-motif in nucleic acids [J].
Guéron, M ;
Leroy, JL .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2000, 10 (03) :326-331
[6]   A gold nanoparticle based approach for screening triplex DNA binders [J].
Han, MS ;
Lytton-Jean, AKR ;
Mirkin, CA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (15) :4954-4955
[7]   Colorimetric screening of DNA-binding molecules with gold nanoparticle probes [J].
Han, MS ;
Lytton-Jean, AKR ;
Oh, BK ;
Heo, J ;
Mirkin, CA .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (11) :1807-1810
[8]  
Kreibig U., 1995, OPTICAL PROPERTIES M, DOI DOI 10.1007/978-3-662-09109-8
[9]   Colorimetric detection of DNA sequences based on electrostatic interactions with unmodified gold nanoparticles [J].
Li, HX ;
Rothberg, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (39) :14036-14039
[10]   Switching the conformation of a DNA molecule with a chemical oscillator [J].
Liedl, T ;
Simmel, FC .
NANO LETTERS, 2005, 5 (10) :1894-1898