RNA in human sperm

被引：49

作者：

Martins, RP ^{[1
]}

Krawetz, SA ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Ctr Mol Med & Genet,Inst Sci Comp, Detroit, MI 48201 USA

来源：

ASIAN JOURNAL OF ANDROLOGY | 2005年 / 7卷 / 02期

关键词：

RNA; siRNA; miRNA; sperm; microarray; fertilization; diagnostics;

D O I：

10.1111/j.1745-7262.2005.00048.x

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

We have yet to develop a fundamental understanding of the molecular complexities of human spermatozoa. This encompasses the unique packaging and structure of the sperm genome along with their paternally derived RNAs in preparation for their delivery to the egg. The diversity of these transcripts is vast, including several anti-sense molecules resembling known regulatory micro-RNAs. The field is still grasping with its delivery to the oocyte at fertilization and possible significance. It remains tempting to analogize them to maternally-derived transcripts active in early embryo patterning. Irrespective of their role in the embryo, their use as a means to assess male factor infertility is promising.

引用

页码：115 / 120

页数：6

共 64 条

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