A light writable microfluidic "flash memory": Optically addressed actuator array with latched operation for microfluidic applications

被引:9
作者
Hua, Zhishan [1 ]
Pal, Rohit [1 ]
Srivannavit, Onnop [1 ]
Burns, Mark A. [1 ]
Gulari, Erdogan [1 ]
机构
[1] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA
关键词
D O I
10.1039/b712983a
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
This paper presents a novel optically addressed microactuator array (microfluidic "flash memory") with latched operation. Analogous to the address-data bus mediated memory address protocol in electronics, the microactuator array consists of individual phase-change based actuators addressed by localized heating through focused light patterns (address bus), which can be provided by a modified projector or high power laser pointer. A common pressure manifold (data bus) for the entire array is used to generate large deflections of the phase change actuators in the molten phase. The use of phase change material as the working media enables latched operation of the actuator array. After the initial light "writing" during which the phase is temporarily changed to molten, the actuated status is self-maintained by the solid phase of the actuator without power and pressure inputs. The microfluidic flash memory can be re-configured by a new light illumination pattern and common pressure signal. The proposed approach can achieve actuation of arbitrary units in a large-scale array without the need for complex external equipment such as solenoid valves and electrical modules, which leads to significantly simplified system implementation and compact system size. The proposed work therefore provides a flexible, energy-efficient, and low cost multiplexing solution for microfluidic applications based on physical displacements. As an example, the use of the latched microactuator array as "normally closed" or "normally open" microvalves is demonstrated. The phase-change wax is fully encapsulated and thus immune from contamination issues in fluidic environments.
引用
收藏
页码:488 / 491
页数:4
相关论文
共 12 条
[1]   A high density microchannel network with integrated valves and photodiodes [J].
Baechi, D ;
Buser, R ;
Dual, J .
SENSORS AND ACTUATORS A-PHYSICAL, 2002, 95 (2-3) :77-83
[2]   An integrated microfluidic processor for single nucleotide polymorphism-based DNA computing [J].
Grover, WH ;
Mathies, RA .
LAB ON A CHIP, 2005, 5 (10) :1033-1040
[3]   Monolithic membrane valves and diaphragm pumps for practical large-scale integration into glass microfluidic devices [J].
Grover, WH ;
Skelley, AM ;
Liu, CN ;
Lagally, ET ;
Mathies, RA .
SENSORS AND ACTUATORS B-CHEMICAL, 2003, 89 (03) :315-323
[4]   Computerized microfluidic cell culture using elastomeric channels and Braille displays [J].
Gu, W ;
Zhu, XY ;
Futai, N ;
Cho, BS ;
Takayama, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (45) :15861-15866
[5]   A nanoliter-scale nucleic acid processor with parallel architecture [J].
Hong, JW ;
Studer, V ;
Hang, G ;
Anderson, WF ;
Quake, SR .
NATURE BIOTECHNOLOGY, 2004, 22 (04) :435-439
[6]   Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics [J].
Lee, CC ;
Sui, GD ;
Elizarov, A ;
Shu, CYJ ;
Shin, YS ;
Dooley, AN ;
Huang, J ;
Daridon, A ;
Wyatt, P ;
Stout, D ;
Kolb, HC ;
Witte, ON ;
Satyamurthy, N ;
Heath, JR ;
Phelps, ME ;
Quake, SR ;
Tseng, HR .
SCIENCE, 2005, 310 (5755) :1793-1796
[7]   Self-contained, fully integrated biochip for sample preparation, polymerase chain reaction amplification, and DNA microarray detection [J].
Liu, RH ;
Yang, JN ;
Lenigk, R ;
Bonanno, J ;
Grodzinski, P .
ANALYTICAL CHEMISTRY, 2004, 76 (07) :1824-1831
[8]   Phase change microvalve for integrated devices [J].
Pal, R ;
Yang, M ;
Johnson, BN ;
Burke, DT ;
Burns, MA .
ANALYTICAL CHEMISTRY, 2004, 76 (13) :3740-3748
[9]   Multifunctional microvalves control by optical illumination on nanoheaters and its application in centrifugal microfluidic devices [J].
Park, Jong-Myeon ;
Cho, Yoon-Kyoung ;
Lee, Beom-Seok ;
Lee, Jeong-Gun ;
Ko, Christopher .
LAB ON A CHIP, 2007, 7 (05) :557-564
[10]   Microfluidic large-scale integration [J].
Thorsen, T ;
Maerkl, SJ ;
Quake, SR .
SCIENCE, 2002, 298 (5593) :580-584