Crystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients

被引：225

作者：

Vishweshwar, P

McMahon, JA

Peterson, ML

Hickey, MB

Shattock, TR

Zaworotko, MJ

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

[2] TransForm Pharmaceut Inc, Lexington, MA 02421 USA

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 36期

关键词：

D O I：

10.1039/b501304f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The carboxylic acid-primary amide supramolecular heterosynthon is exploited for the generation of pharmaceutical co-crystals that contain two active pharmaceutical ingredients that are polymorphic in their pure forms.

引用

页码：4601 / 4603

页数：3

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