Organic synthesis in pursuit of immunology: Large-scale synthesis of peracetylated GM2 glycosylamino acid for preparation of a multiantigenic prostate cancer vaccine

被引：15

作者：

Cho, YS

Wan, Q

Danishefsky, SJ

机构：

[1] Sloan Kettering Inst Canc Res, Bioorgan Chem Lab, New York, NY 10021 USA

[2] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 17期

关键词：

D O I：

10.1016/j.bmc.2005.06.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe herein the stereocontrolled, large-scale synthesis of peracetylated GM2 glycosylamino acid. Key features of the synthesis include a newly modified [1 + 3] coupling reaction and an olefin cross-metathesis-hydrogenation sequence. The GM2 glycosylarnino acid is now ready for incorporation into a hexavalent prostate cancer vaccine construct. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：5259 / 5266

页数：8

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