Purinergic signalling and disorders of the central nervous system

被引：516

作者：

Burnstock, Geoffrey ^{[1
]}

机构：

[1] UCL Royal Free & Univ Coll Med Sch, Auton Neurosci Ctr, London NW3 2PF, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2008年 / 7卷 / 07期

关键词：

D O I：

10.1038/nrd2605

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

Purines have key roles in neurotransmission and neuromodulation, with their effects being mediated by the purine and pyrimidine receptor subfamilies, P1, P2X and P2Y. Recently, purinergic mechanisms and specific receptor subtypes have been shown to be involved in various pathological conditions including brain trauma and ischaemia, neurodegenerative diseases involving neuroimmune and neuroinflammatory reactions, as well as in neuropsychiatric diseases, including depression and schizophrenia. This article reviews the role of purinergic signalling in CNS disorders, highlighting specific purinergic receptor subtypes, most notably A(2A), P2X(4) and P2X(7), that might be therapeutically targeted for the treatment of these conditions.

引用

页码：575 / 590

页数：16

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