Polymer Fibrous Materials Composed of Sodium Carboxymethylcellulose and Poly(vinyl alcohol) for a Hydrophilic Anticancer Drug Release

被引：4

作者：

Cai, Xiaoqing ^{[1
,2
]}

Zhao, Qingyun

Luan, Yuxia ^{[1
,2
]}

Jiang, Yue ^{[1
,2
]}

Shi, Jiaojiao ^{[1
,2
]}

Shao, Wei ^{[1
,2
]}

机构：

[1] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Ctr Pharmaceut Res & Drug Delivery Syst, Jinan 250012, Shandong, Peoples R China

来源：

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY | 2012年 / 33卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Drug release; drug-loaded fiber; NaCMC; PVA; NANOPARTICLES; NANOFIBERS;

D O I：

10.1080/01932691.2011.590415

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Fluorouracil-loaded polymer fibers were prepared by a simple and generic freeze drying technique, in which sodium carboxymethylcellulose (NaCMC) and poly(vinyl alcohol) (PVA) solution containing 5-fluorouracil (5-Fu) was frozen using liquid nitrogen. By controlling the total polymer concentration and the ratio of NaCMC/PVA, 5-Fu-loaded polymer fibers can be obtained. The synthesized 5-Fu-loaded NaCMC/PVA fibers are characterized with scanning electron microscopy (SEM), powder x-ray diffraction (XRD), and differential scanning calorimetry (DSC). The drug release behavior of the as-prepared products is studied to reveal their potential use in drug delivery system.

引用

页码：835 / 839

页数：5

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