Immunopathological Roles of Cytokines, Chemokines, Signaling Molecules, and Pattern-Recognition Receptors in Systemic Lupus Erythematosus

被引：64

作者：

Yu, Shui-Lian ^{[1
]}

Kuan, Woon-Pang ^{[2
]}

Wong, Chun-Kwok ^{[3
]}

Li, Edmund K. ^{[1
]}

Tam, Lai-Shan ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China

[2] Hosp Selayang, Dept Rheumatol, Lebuhraya Selayang Kepon 68100, Batu Caves, Malaysia

[3] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Chem Pathol, Shatin, Hong Kong, Peoples R China

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2012年

关键词：

TOLL-LIKE RECEPTORS; HELPER T-CELLS; SQUAMOUS INTRAEPITHELIAL LESIONS; PLASMACYTOID DENDRITIC CELLS; ACTIVATED PROTEIN-KINASE; UP-REGULATED EXPRESSION; BLOOD MONONUCLEAR-CELLS; EPSTEIN-BARR-VIRUS; NOD-LIKE RECEPTORS; BXSB-YAA MICE;

D O I：

10.1155/2012/715190

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Systemic lupus erythematosus (SLE) is an autoimmune disease with unknown etiology affecting more than one million individuals each year. It is characterized by B- and T-cell hyperactivity and by defects in the clearance of apoptotic cells and immune complexes. Understanding the complex process involved and the interaction between various cytokines, chemokines, signaling molecules, and pattern-recognition receptors (PRRs) in the immune pathways will provide valuable information on the development of novel therapeutic targets for treating SLE. In this paper, we review the immunopathological roles of novel cytokines, chemokines, signaling molecules, PRRs, and their interactions in immunoregulatory networks and suggest how their disturbances may implicate pathological conditions in SLE.

引用

页数：14

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